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Magnetic Resonance Neuroimaging pp 251–270Cite as

Magnetic Resonance Imaging-Based Mouse Brain Atlas and Its Applications

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 711))

Abstract

In this chapter, we introduce modern magnetic resonance imaging (MRI)-based mouse brain atlases. Although unable to match the resolution and specificity of their histology-based counterparts, MRI-based mouse brain atlases feature higher anatomical fidelity and can facilitate high-throughput computer-assisted analysis of certain brain phenotypes. This chapter discusses several technical aspects of MRI-based mouse brain atlases, which are important to understand the usefulness as well as limitations of existing atlases. We focus on a novel MRI technique, diffusion tensor imaging (DTI), which provides rich tissue contrasts and is uniquely suited for studying white matter structures and immature mouse brains. The chapter then demonstrates several applications of MRI-based mouse brain atlases in anatomical phenotyping and guiding stereotaxic operations.

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Author information

Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology and Radiological Science, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Manisha Aggarwal

  2. The Russell H. Morgan Department of Radiology and Radiological Science, F.M. Kirby Research Center for Functional Brain Imaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jiangyang Zhang

  3. The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Susumu Mori

Authors
  1. Manisha Aggarwal
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  2. Jiangyang Zhang
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  3. Susumu Mori
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Corresponding author

Correspondence to Jiangyang Zhang .

Editor information

Editors and Affiliations

  1. Institute of Psychiatry, Department of Neuroscience, King's College London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Michel Modo

  2. Institute of Cell Engineering, Dept Radiology & Radiological Sciences, Johns Hopkins Univ. Sch. of Med., Rutland Ave. 720, Baltimore, 21205, Maryland, USA

    Jeff W.M. Bulte

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Aggarwal, M., Zhang, J., Mori, S. (2011). Magnetic Resonance Imaging-Based Mouse Brain Atlas and Its Applications. In: Modo, M., Bulte, J. (eds) Magnetic Resonance Neuroimaging. Methods in Molecular Biology, vol 711. Humana Press. https://doi.org/10.1007/978-1-61737-992-5_12

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  • DOI: https://doi.org/10.1007/978-1-61737-992-5_12

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61737-991-8

  • Online ISBN: 978-1-61737-992-5

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