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High-Field MRI of Brain Iron

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Magnetic Resonance Neuroimaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 711))

Abstract

Recent developments in high-field MRI have provided opportunities to detect iron in human brain with much improved sensitivity. The combination of increased magnetic field strength with multi-channel detectors has made it possible to routinely obtain images at about 300 μm resolution. These images can be sensitized to tissue iron by exploiting the improved magnetic susceptibility contrast at high field. Together, these techniques have the potential to map the fine scale distribution of iron in human brain at the level of fiber bundles and cortical laminae, and may aid in the understanding of the role and transport of iron in normal brain and in disease. In this chapter, we will look at these techniques in detail and present some examples of high-field MRI data of human brain.

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Acknowledgments

My colleagues in the laboratory of Advanced MRI are acknowledged for their contributions to this work. This research was supported by the Intramural Research Program of NIH, NINDS.

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Authors and Affiliations

  1. Advanced MRI Section, National Institute for Neurological Disease and Stroke, National Institute of Health, Bethesda, MD, USA

    Jozef H. Duyn

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  1. Jozef H. Duyn
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Correspondence to Jozef H. Duyn .

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Editors and Affiliations

  1. Institute of Psychiatry, Department of Neuroscience, King's College London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Michel Modo

  2. Institute of Cell Engineering, Dept Radiology & Radiological Sciences, Johns Hopkins Univ. Sch. of Med., Rutland Ave. 720, Baltimore, 21205, Maryland, USA

    Jeff W.M. Bulte

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Duyn, J.H. (2011). High-Field MRI of Brain Iron. In: Modo, M., Bulte, J. (eds) Magnetic Resonance Neuroimaging. Methods in Molecular Biology, vol 711. Humana Press. https://doi.org/10.1007/978-1-61737-992-5_11

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  • DOI: https://doi.org/10.1007/978-1-61737-992-5_11

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61737-991-8

  • Online ISBN: 978-1-61737-992-5

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