Characterization of Nitric Oxide Delivery Systems Produced By Various Nanotechnologies
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Advanced formulations having the capability of long-term protection and preserving the integrity of the nitric oxide molecule were developed for the efficient delivery of nitric oxide. The methods for the production and delivery of nitric oxide produced from diethylenetriamine diazeniumdiolate or S-nitrosoglutathione as a nitric oxide donor to desired target sites in a controlled and sustained release manner are described. The pharmacological assessments of advanced formulations using in vitro and in vivo tests are also described in detail. These systems can be used for the treatment of cardiovascular diseases and sexual dysfunctions.
Key wordsNitric oxide delivery PLGA microparticle polymeric GSNO film cell cytotoxicity blood flow
This work was partly supported with a grant from the Missouri Life Science Research Board (09-1117). The author would like to thank Dr. Jin-Wook Yoo for his contribution to the formulation development and evaluation processes and Dr. Peter Smith in KUMC for lending us the laser Doppler.
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