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Adipose-Derived Stem Cells pp 461–470Cite as

Adipose-Derived Stem Cells for Periodontal Tissue Regeneration

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 702))

Abstract

Mesenchymal stem cells can effectively regenerate destroyed periodontal tissue. Because periodontal tissues are complex, mesenchymal stem cells that can differentiate into many tissue types would aid periodontal tissue regeneration. Indeed, periodontal tissue regeneration using mesenchymal stem cells derived from adipose tissue or bone marrow has been performed in experimental animal models, such as rat, canine, swine, and monkey. We have shown that rat periodontal tissue can be regenerated with adipose-derived stem cells. Adipose tissue contains a large number of stromal cells and is relatively easy to obtain in large quantities, and thus constitutes a very convenient stromal cell source. In this chapter, we introduce a rat periodontal tissue regeneration model using adipose-derived stem cells.

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Acknowledgments

The authors would like to thank Ms. Miyuki Takatori and Mr. Hidemasa Takafuji, the Center for Life Science, Nippon Medical School, for their expert assistance with the animal experiments and histological analyses. This work was supported in part by the Japanese Ministry of Education, Sports, and Culture (Grant number: 17591878).

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Authors and Affiliations

  1. Office of Surgeon General and Director of Medicine, Maritime Staff Office, Ministry of Defense, Tokyo, Japan

    Morikuni Tobita

  2. Department of Plastic and Reconstructive Surgery, School of Medicine, Juntendo University, Tokyo, Japan

    Hiroshi Mizuno

Authors
  1. Morikuni Tobita
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  2. Hiroshi Mizuno
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Corresponding author

Correspondence to Hiroshi Mizuno .

Editor information

Editors and Affiliations

  1. , Stem Cell Biology, Pennington Biomedical Research Center, Perkins Rd. 6400, Baton Rouge, 70808, Louisiana, USA

    Jeffrey M. Gimble

  2. School of Medicine, Department of Pharmacology, Tulane University, Tulane Ave. 1430, New Orleans, 70112-2699, Louisiana, USA

    Bruce A. Bunnell

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Tobita, M., Mizuno, H. (2011). Adipose-Derived Stem Cells for Periodontal Tissue Regeneration. In: Gimble, J., Bunnell, B. (eds) Adipose-Derived Stem Cells. Methods in Molecular Biology, vol 702. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61737-960-4_34

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  • DOI: https://doi.org/10.1007/978-1-61737-960-4_34

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-959-8

  • Online ISBN: 978-1-61737-960-4

  • eBook Packages: Springer Protocols

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