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APOE-Based Models of “Pre-Dementia”

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Animal Models of Dementia

Part of the book series: Neuromethods ((NM,volume 48))

Abstract

Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding the etiology and progression of late-onset Alzheimer’s disease (AD). Unfortunately, no such model exists. Herein, I review all past and present attempts to create an APOE-based model with suggestions on how to reproduce AD in a mouse. Our ability to succeed in recreating late-onset AD will depend on the identification of new genetic markers in addition to the validation of nongenetic factors thought to increase the risk of dementia. These new factors can then be incorporated into an APOE-expressing animal for mechanistic studies and identification of new drug targets.

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Author information

Authors and Affiliations

  1. Center for Aging/Division of Geriatrics, Duke University Medical Center, Durham, NC, USA

    Patrick M. Sullivan

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  1. Patrick M. Sullivan
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Editor information

Editors and Affiliations

  1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Peter Paul De Deyn

  2. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Debby Van Dam

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Sullivan, P.M. (2011). APOE-Based Models of “Pre-Dementia”. In: De Deyn, P., Van Dam, D. (eds) Animal Models of Dementia. Neuromethods, vol 48. Humana Press. https://doi.org/10.1007/978-1-60761-898-0_22

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  • DOI: https://doi.org/10.1007/978-1-60761-898-0_22

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-897-3

  • Online ISBN: 978-1-60761-898-0

  • eBook Packages: Springer Protocols

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