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Animal Models of Dementia: Ethical Considerations

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Animal Models of Dementia

Part of the book series: Neuromethods ((NM,volume 48))

Abstract

This chapter aims to encourage scientists and others interested in the use of animal models of disease – specifically, in the study of dementia – to engage in ethical reflection. It opens with a general discussion of the moral acceptability of animal use in research. Three ethical approaches are here distinguished. These serve as points of orientation in the following discussion of four more specific ethical questions: Does animal species matter? How effective is disease modelling in delivering the benefits claimed for it? What can be done to minimize potential harm to animals in research? Who bears responsibility for the use of animals in disease models?

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References

  1. Sandøe P, Christiansen S (2008) Ethics of ­animal use. Blackwell, Oxford, UK

    Google Scholar 

  2. Narveson J (1983) Animal rights revisited. In: Miller HB, Williams WH (eds) Ethics and ­animals. Humana, Clifton, NJ

    Google Scholar 

  3. Singer P (1989) All animals are equal. In: Regan T, Singer P (eds) Animal rights and human obligations. Prentice Hall, Englewood Cliffs, NJ, pp 73–86

    Google Scholar 

  4. Regan T (1988) The case for animal rights. Routledge, London

    Google Scholar 

  5. Russell WMS, Burch RL (2008) The principles of humane experimental technique 1959 (Accessed June 9, 2008 at http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm)

  6. Singer P (1975) Animal liberation 2nd edition. Thorsons, London (1st edition 1975)

    Google Scholar 

  7. Nagel T (1974) What is it like to be a bat? Philos Rev 83:435–450

    Article  Google Scholar 

  8. Smith JA, Boyd KM (1991) Lives in the balance: The ethics of using animals in biomedical research. Oxford University Press, Oxford, UK

    Google Scholar 

  9. Ashley PJ, Sneddon LU (2008) Pain and fear in fish. In: Branson EJ (ed) Fish welfare. Blackwell, UK, pp 49–77

    Chapter  Google Scholar 

  10. Braithwaite VA, Boulcott P (2008) Can fish suffer? In: Branson EJ (ed) Fish welfare. Blackwell, UK, pp 78–92

    Chapter  Google Scholar 

  11. Arluke A, Sanders CR (1996) Regarding ­animals. Temple University Press, Philadelphia, PA.

    Google Scholar 

  12. Grotewiel MS, Martin I, Bhandari P, et al. (2005) Functional senescence in Drosophila melanogaster. Ageing Res Rev 4:372–397

    Article  PubMed  CAS  Google Scholar 

  13. Murakami S (2007) Caenorhabditis elegans as a model system to study aging of learning and memory. Mol Neurobiol 35:85–94

    Article  PubMed  CAS  Google Scholar 

  14. Eismann CH, Jorgensen WK, Merritt DJ, Rice MJ, et al. (1984) Do insects feel pain? A biological view. Experientia 40:164–167

    Article  Google Scholar 

  15. Lockwood JA (1987) The moral standing of insects and the ethics of extinction. Fla Entomol 70:70–89

    Article  Google Scholar 

  16. Sherwin C (2001) Can invertebrates suffer? Or, how robust is argument–by analogy? Anim Welfare 10:S103–S118

    Google Scholar 

  17. Guo S (2004) Linking genes to brain, ­behavior and neurological diseases: What can we learn from zebrafish? Genes Brain Behav 3:63–74

    Article  PubMed  CAS  Google Scholar 

  18. Aldhous P, Coghlan A, Copley J (1999) Let the people speak. New Sci 2187:26

    Google Scholar 

  19. Cohen J (2007) The endangered lab chimp. Science 315:450–452

    Article  PubMed  CAS  Google Scholar 

  20. Tayebati SK (2006) Animal models of cognitive dysfunctions. Mech Ageing Dev 127:100–108

    Article  PubMed  Google Scholar 

  21. Weatherall D, Goodfellow P, Harris J (2006) The use of non-human primates in research – a working group report, London

    Google Scholar 

  22. Price E (1999) Behavioral development in animals undergoing domestication. Appl Anim Beh Sci 65:245–271

    Article  Google Scholar 

  23. Smith JA, van den Broek FAR, Canto Martorell J, et al. (2007) Principles and practice in ethical review of animal experiments across Europe: summary of the report of a FELASA working group on ethical evaluation of animal experiments. Lab Anim 41:143–160

    Article  PubMed  Google Scholar 

  24. Marx U, Embleton J, Fischer R, et al. (1997) Monoclonal antibody production. The Report and Recommendations of ECVAM Workshop 231. ATLA 25:121–137

    Google Scholar 

  25. Van der Warp HB, de Haan P, Morrema E, et al. (2005) Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. J Neurol 252:1108–1114

    Article  Google Scholar 

  26. Macleod M, Sandercock P (2005) Systematic reviews improve clinical research design – can they help improve animal experimental work? RDS News Winter issue

    Google Scholar 

  27. Van der Staay FJ (2006) Animal models of behavioral dysfunctions: Basic concepts and classifications, and an evaluation strategy. Brain Res Rev 52:131–159

    Article  PubMed  Google Scholar 

  28. Schliebs R, Rossner S, Bigl V (1996) Immuno­lesion by 192IgG-saporin of rat basal forebrain cholinergic system: A useful tool to produce cortical cortical cholinergic dysfunction. Prog Brain Res 109:253–264

    Article  PubMed  CAS  Google Scholar 

  29. Morton D (2007) Experimental procedures: general principles and recommendations. In: Kalista E (ed) The welfare of animals. Springer, Dordrecht, The Netherlands, pp 81–115

    Chapter  Google Scholar 

  30. Richardson CA, Flecknell PA (2005) Anaes­thesia and post-operative analgesia following experimental surgery in laboratory rodents: Are we making progress? ATLA 33:119–127

    PubMed  CAS  Google Scholar 

  31. Perel VD (1998) Psychosocial impact of Alzheimer disease. J Amer Med Assoc 279:1038–1039

    Article  CAS  Google Scholar 

  32. Apostolova LG, Cummings JL (2008) Neuropsychiatric manifestations in mild cognitive impairment: A systematic review of the literature. Dement Geriatr Cogn 25:115–126

    Article  Google Scholar 

  33. Bradshaw J, Casey R, Blackwell E (2007) Principles of companion animal behaviour therapy. Blackwell Science, UK

    Google Scholar 

  34. Olsson IAS, Dahlborn K (2002) Improving housing conditions for laboratory mice: a review of ‘environmental enrichment’. Lab Anim 36:243–270

    Article  PubMed  CAS  Google Scholar 

  35. Wolfer DP, Litvin L, Morf S, et al. (2004) Laboratory animal welfare: Cage enrichment and mouse behaviour. Nature 432:821–822

    Article  PubMed  CAS  Google Scholar 

  36. Nithianantharajah J, Hannan AJ (2006) Enriched environments, experience dependent plasticity and disorders of the nervous system. Nature Rev Neurosci 7:697–709

    Article  CAS  Google Scholar 

  37. Bard F, Cannon C, Barbour R, et al. (2000) Peripherally administered antibodies against amyloid -peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916–919

    Article  PubMed  CAS  Google Scholar 

  38. Van Dam D, de Deyn PP (2006) Drug discovery in dementia: the role of rodent models. Nature Rev Drug Discov 5:956–970

    Article  CAS  Google Scholar 

  39. Bacskai BJ, Kajdasz ST, Christie RH, et al. (2001) Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 7:369–372

    Article  PubMed  CAS  Google Scholar 

  40. European Union. Treaty of Amsterdam amending the Treaty on European Union, the Treaties establishing the European Communities and related acts. Official Journal C 340, 10 November 1997 (Accessed June 3, 2009 at http://eur-lex.europa.eu/en/treaties/dat/11997D/htm/11997D.html)

  41. Olsson IAS, Hansen AK, Sandøe P (2007) Ethics and refinement in animal research. Science 317:1680

    Article  PubMed  CAS  Google Scholar 

  42. Olsson IAS, Hansen AK, Sandøe P (2008) Animal welfare and the refinement of neuroscience research methods – a case study of Huntington’s disease models. Lab Anim 42:277–283

    Article  PubMed  CAS  Google Scholar 

  43. Greek R (2005) Animal rights extremism revisited. The Scientist Nov 7

    Google Scholar 

  44. Matthews RAJ (2008) Medical progress depends on animal models – doesn’t it? J R Soc Med 101:95–98

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory Animal Science, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

    I. Anna S. Olsson

  2. Danish Centre for Bioethics and Risk Assessment, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark

    I. Anna S. Olsson & Peter Sandøe

Authors
  1. I. Anna S. Olsson
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  2. Peter Sandøe
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Editor information

Editors and Affiliations

  1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Peter Paul De Deyn

  2. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Debby Van Dam

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Olsson, I.A.S., Sandøe, P. (2011). Animal Models of Dementia: Ethical Considerations. In: De Deyn, P., Van Dam, D. (eds) Animal Models of Dementia. Neuromethods, vol 48. Humana Press. https://doi.org/10.1007/978-1-60761-898-0_2

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  • DOI: https://doi.org/10.1007/978-1-60761-898-0_2

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-897-3

  • Online ISBN: 978-1-60761-898-0

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