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Zebrafish (Danio rerio) as a Model Organism for Dementia

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Animal Models of Dementia

Part of the book series: Neuromethods ((NM,volume 48))

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Abstract

Zebrafish, a freshwater tropical fish, is a premiere model organism to study vertebrate development. Fast external development and transparency during embryogenesis allow for visual screening at the macroscopical and microscopical level, including visualization of organogenesis. High fecundity and short generation times facilitate genetic analyses. Zebrafish may be a particular powerful model for the study of human disease because many cellular processes are conserved throughout vertebrate evolution, including the corresponding disease genes. Finally, the ability to manipulate gene expression has broad usefulness in the study of modeling human disease, including dementia.

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Author information

Authors and Affiliations

  1. Departments of Clinical Genetics and Neurology, Erasmus MC, Rotterdam, The Netherlands

    Rob Willemsen, Sandra van’t Padje, John C. van Swieten & Ben A. Oostra

Authors
  1. Rob Willemsen
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  2. Sandra van’t Padje
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  3. John C. van Swieten
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  4. Ben A. Oostra
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Editor information

Editors and Affiliations

  1. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Peter Paul De Deyn

  2. Institute Born-Bunge, Lab of Neurochemistry & Behaviour, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium

    Debby Van Dam

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© 2011 Springer Science+Business Media, LLC

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Willemsen, R., Padje, S.v., van Swieten, J.C., Oostra, B.A. (2011). Zebrafish (Danio rerio) as a Model Organism for Dementia. In: De Deyn, P., Van Dam, D. (eds) Animal Models of Dementia. Neuromethods, vol 48. Humana Press. https://doi.org/10.1007/978-1-60761-898-0_14

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  • DOI: https://doi.org/10.1007/978-1-60761-898-0_14

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-897-3

  • Online ISBN: 978-1-60761-898-0

  • eBook Packages: Springer Protocols

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