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A Comparative Analysis of Cellular Morphological Differentiation Within the Cerebral Cortex Using Diffusion Tensor Imaging

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Animal Models of Behavioral Analysis

Part of the book series: Neuromethods ((NM,volume 50))

Abstract

Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that provides information about cellular microstructure through measurements of water diffusion. Because inferences about neuroanatomy can be made from DTI, this methodology has been used to characterize cellular morphological changes associated with development of the cerebral cortex. Currently, however, the specific anatomical changes associated with DTI measurements directed at the cerebral cortex are incompletely characterized. Here, data collected in several laboratories, investigating five species (mouse, rat, ferret, baboon, and human), are compared to determine whether similarities in the trajectory of DTI measurements with development exist in the literature. Specifically, rates of change in fractional anisotropy (FA) of water diffusion were compared to rates of neuroanatomical development (based on the occurrence of specific neural events) in each species. In all species, decreases in FA with development were accurately approximated by fitting data to the same mathematical expression of exponential decay. Additionally, a high degree of correlation was found between rates of FA decay and rates of neuroanatomical development. This suggests that a common mechanism underlies decreases in FA with development across species. These results have two major implications. The ability of DTI to detect changes in neuroanatomy in the normal developing cerebral cortex introduces the potential for the use of this methodology in detecting cortical abnormalities associated with various developmental disorders. Additionally, the comparable patterns of neurodevelopment, and hence FA, across species imply that DTI methodology applied in non-human species can provide information about the human condition.

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Acknowledgments

This work was supported by National Institutes of Health Grant T32 AA007468-22 and the OHSU 11.7 T MRI system is supported by the Keck Foundation. The authors would like to thank Jaime F. Olavarria for helpful discussion during the preparation of this manuscript.

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  1. Department of Behavioral Neuroscience, Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA

    Lindsey A. Leigland & Christopher D. Kroenke

  2. Oregon Health and Science University, Portland, OR, 97239, USA

    Christopher D. Kroenke

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  1. Lindsey A. Leigland
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  1. , Dept. of Behavioral Neuroscience, Oregon Health & Science University, SW. Sam Jackson Park Road 3181, Portland, 97239-3098, Oregon, USA

    Jacob Raber

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Leigland, L.A., Kroenke, C.D. (2011). A Comparative Analysis of Cellular Morphological Differentiation Within the Cerebral Cortex Using Diffusion Tensor Imaging. In: Raber, J. (eds) Animal Models of Behavioral Analysis. Neuromethods, vol 50. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-883-6_13

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  • DOI: https://doi.org/10.1007/978-1-60761-883-6_13

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