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Evaluating Behavioral Outcomes from Ischemic Brain Injury

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Animal Models of Behavioral Analysis

Part of the book series: Neuromethods ((NM,volume 50))

Abstract

Brain injury resulting from cerebral ischemia is a significant clinical problem. Stroke (focal cerebral ischemia) is the third leading cause of death in the United States. In addition, approximately 500,000 people annually in the United States suffer brain injury after global brain ischemia consequent to cardiac arrest and cardiopulmonary resuscitation (CPR). Despite intensive research over the past few decades, survival and neurological outcome for both types of ischemic injury remain poor. Therefore, the need for therapies to protect the brain during ischemic episodes and to enhance its potential for plasticity and repair after ischemia remains paramount. This chapter discusses behavioral techniques and considerations that are vital to brain injury studies of experimental stroke or cardiac arrest. Testing protocols are focused on the mouse, as this species is readily amenable to genetic alteration and so has rapidly become the dominant species employed in most laboratories.

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Acknowledgments

We gratefully acknowledge Ms Kathy Gage for her editing expertise. Supported by NIH NS 49210.

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Authors and Affiliations

  1. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Paco S. Herson, Julie Palmateer & Patricia D. Hurn

  2. Department of Psychology, The Ohio State University, Columbus, OH, USA

    A. Courtney DeVries

Authors
  1. Paco S. Herson
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  2. Julie Palmateer
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  3. Patricia D. Hurn
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  4. A. Courtney DeVries
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Corresponding author

Correspondence to Paco S. Herson .

Editor information

Editors and Affiliations

  1. , Dept. of Behavioral Neuroscience, Oregon Health & Science University, SW. Sam Jackson Park Road 3181, Portland, 97239-3098, Oregon, USA

    Jacob Raber

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Herson, P.S., Palmateer, J., Hurn, P.D., DeVries, A.C. (2011). Evaluating Behavioral Outcomes from Ischemic Brain Injury. In: Raber, J. (eds) Animal Models of Behavioral Analysis. Neuromethods, vol 50. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-883-6_12

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  • DOI: https://doi.org/10.1007/978-1-60761-883-6_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-882-9

  • Online ISBN: 978-1-60761-883-6

  • eBook Packages: Springer Protocols

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