Immunosuppressive Mechanisms During Viral Infectious Diseases

  • Ghanashyam Sarikonda
  • Matthias G. von HerrathEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 677)


For a virus to establish persistence in the host, it has to exploit the host immune system such that the active T-cell responses against the virus are curbed. On the other hand, the goal of the immune system is to clear the virus, following which the immune responses need to be downregulated, by a process known as immunoregulation. There are multiple known immunoregulatory mechanisms that appear to play a role in persistent viral infections. In the recent past, IL-10 and PD-1 have been identified to be playing a significant role in the regulation of antiviral immune responses. The evidence that viruses can escape immunologic attack by taking advantage of the host’s immune system is found in LCMV infection of mice and in humans persistently infected with HIV and HCV. The recent observation that the functionally inactive T-cells during chronic viral infections can be made to regain their cytokine secretion and cytolytic abilities is very encouraging. Thus, it would be likely that neutralization negative immune regulation during persistent viral infection would result in the preservation of effector T-cell responses against the virus, thereby resulting in the elimination of the persistent infection.

Key words

Immunoregulation Persistent infection IL-10 PD-1 LCMV 


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Copyright information

© Humana Press 2010

Authors and Affiliations

  • Ghanashyam Sarikonda
    • 1
  • Matthias G. von Herrath
    • 2
    Email author
  1. 1.Department of Developmental Immunology-3,Diabetes Center of San DiegoLa Jolla Institute for Allergy and ImmunologyLa JollaUSA
  2. 2.Department of Developmental Immunology (D1-3), Diabetes Center of San DiegoLa Jolla Institute for Allergy and ImmunologyLa JollaUSA

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