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Immunoregulatory Properties of Heme Oxygenase-1

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Suppression and Regulation of Immune Responses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 677))

Abstract

Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli. A growing body of evidence points toward the capacity of this molecule to inhibit immune reactions and the pivotal role of HO-1 in inflammatory diseases. We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devoted to the use of an HO-1 inducer as an immunosuppressive molecule in transplantation. Finally, we will review the molecular basis of HO-1 actions on different immune cells.

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Acknowledgments

This work was supported by funding from, La Région Pays de la Loire through the “Chaire d’excellence program” for AK and the IMBIO program, l’Agence de la Biomédecine, Ministère de la Recherche, Fondation CENTAURE, Fondation Progreffe, an ECOS France-Chile grant and Millennium Nucleus on Immunology and Immunotherapy from Chile (P04/030-F). LC is a CONICYT fellow.

Author information

Authors and Affiliations

  1. ONIRIS, Nantes, France

    Philippe Blancou

  2. INRA, UMR_A 707, Nantes, France

    Philippe Blancou

  3. INSERM UMR 643, Nantes, France

    Virginie Tardif, Thomas Simon, Séverine Rémy & Ignacio Anegon

  4. Institut de Transplantation et de Recherche en Transplantation (ITERT), CHU Nantes, Nantes, France

    Virginie Tardif, Thomas Simon, Séverine Rémy & Ignacio Anegon

  5. Faculté de Médecine, Université de Nantes, Nantes, France

    Virginie Tardif, Thomas Simon, Séverine Rémy & Ignacio Anegon

  6. Millenium Nucleus of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Catolica de Chile, Santiago, Chile

    Leandro Carreño & Alexis Kalergis

Authors
  1. Philippe Blancou
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  2. Virginie Tardif
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  3. Thomas Simon
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  4. Séverine Rémy
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  5. Leandro Carreño
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  6. Alexis Kalergis
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  7. Ignacio Anegon
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Corresponding author

Correspondence to Philippe Blancou .

Editor information

Editors and Affiliations

  1. CHUHotel Dieu, INSERM UMR 643, Bd. Jean Monnet 30, Nantes, 44093, France

    Maria Cristina Cuturi

  2. CHU Hotel Dieu, INSERM UMR 643, Bd. Jean Monnet 30, Nantes, 44093, France

    Ignacio Anegon

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© 2010 Humana Press

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Blancou, P. et al. (2010). Immunoregulatory Properties of Heme Oxygenase-1. In: Cuturi, M., Anegon, I. (eds) Suppression and Regulation of Immune Responses. Methods in Molecular Biology, vol 677. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-869-0_18

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  • DOI: https://doi.org/10.1007/978-1-60761-869-0_18

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-868-3

  • Online ISBN: 978-1-60761-869-0

  • eBook Packages: Springer Protocols

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