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The Expanding World of Small Molecule Microarrays

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Small Molecule Microarrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 669))

Abstract

Speed and throughput are vital ingredients for discovery-driven, “-omics” research. The small molecule microarray is one such platform, which delivers phenomenal screening throughput and capabilities. The concept at the heart of the technology is elegant, yet simple: by presenting large collections of molecules at a high density on a flat surface, one is able to interrogate them quickly and conveniently, evaluating all possible interactions in a single step. SMMs have, over the last decade, been established as a robust platform for screening, lead discovery, and molecular characterization. In this chapter, we describe the ways in which microarrays have been constructed and applied, focusing on the practical challenges faced when designing and performing SMM experiments. This is written as an introduction for new readers to the field, explaining the key principles and laying the foundation for the chapters that follow.

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Acknowledgments

We gratefully acknowledge financial support by MOE (R143-000-394-112), BMRC (R143-000-391-305), CRP (R143-000-218-281), and DSO National Laboratories.

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Authors and Affiliations

  1. DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore, Singapore

    Mahesh Uttamchandani

  2. Deparments of Chemistry and Biological Sciences, National University of Singapore, Singapore, Singapore

    Mahesh Uttamchandani

  3. Departments of Chemistry and Biological Sciences, and The NUS MedChem Program of the Office of Life Science, Faculty of Science, National University of Singapore, Singapore, Singapore

    Shao Q. Yao

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  1. Mahesh Uttamchandani
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  1. , DSO National Laboratories, Defence Medical and Environmental Resear, 27 Medical Drive, Singapore, 117510, Singapore

    Mahesh Uttamchandani

  2. Faculty of Science, Depts. Chemistry & Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore

    Shao Q. Yao

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Uttamchandani, M., Yao, S.Q. (2010). The Expanding World of Small Molecule Microarrays. In: Uttamchandani, M., Yao, S. (eds) Small Molecule Microarrays. Methods in Molecular Biology, vol 669. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-845-4_1

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  • DOI: https://doi.org/10.1007/978-1-60761-845-4_1

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