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Heparin and Low-Molecular Weight Heparins in Thrombosis and Beyond

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Anticoagulants, Antiplatelets, and Thrombolytics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 663))

Abstract

Heparin and its improved version, low-molecular weight heparin (LMWH), are known to exert polypharmacological effects at various levels. Early studies focused on the plasma anti-Xa and anti-IIa pharmacodynamics of different LMWHs. Other important pharmacodynamic parameters for heparin and LMWH, including effects on vascular tissue factor pathway inhibitor (TFPI) release, inhibition of inflammation through NFκB, inhibition of key matrix-degrading enzymes, selectin modulation, inhibition of platelet–cancer cell interactions, and inflammatory cell adhesion, help explain the diverse clinical impact of this class of agents in thrombosis and beyond.

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  1. Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA

    Shaker A. Mousa

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    Shaker A. Mousa

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Mousa, S.A. (2010). Heparin and Low-Molecular Weight Heparins in Thrombosis and Beyond. In: Mousa, S. (eds) Anticoagulants, Antiplatelets, and Thrombolytics. Methods in Molecular Biology, vol 663. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-803-4_3

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  • DOI: https://doi.org/10.1007/978-1-60761-803-4_3

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