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Systems Biology in Drug Discovery and Development pp 181–201Cite as

Systems Biology and Inflammation

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 662))

Abstract

Inflammation is a complex, multiscale biological response to threats – both internal and external – to the body, which is also required for proper healing of injured tissue. In turn, damaged or dysfunctional tissue stimulates further inflammation. Despite continued advances in characterizing the cellular and molecular processes involved in the interactions between inflammation and tissue damage, there exists a significant gap between the knowledge of mechanistic pathophysiology and the development of effective therapies for various inflammatory conditions. We have suggested the concept of translational systems biology, defined as a focused application of computational modeling and engineering principles to pathophysiology primarily in order to revise clinical practice. This chapter reviews the existing, translational applications of computational simulations and related approaches as applied to inflammation.

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Acknowledgments

The authors would like to acknowledge the contributions to this work of the following investigators, students, and postdoctoral fellows: Arie Baratt, Timothy R. Billiar, Frederick D. Busche, David Carney, Carson Chow, Gilles Clermont, Gregory Constantine, Judy Day, Edwin Dietch, Russell Delude, Joyeeta Dutta-Moscato, G. Bard Ermentrout, James Faeder, Rena Feinman, Ali Ghuma, Mitchell P. Fink, David Hackam, Rukmini Kumar, Claudio Lagoa, Ryan M. Levy, Nicole Li, Qi Mi, Maxim Mikheev, Rajaie Namas, Gary Nieman, Patricio Polanco, Jose M. Prince, Juan Carlos Puyana, Angela Reynolds, Beatrice Riviere, Jonathan Rubin, Matthew Rosengart, David L. Steed, Joshua Sullivan, David Swigon, Andres Torres, Jeffrey Upperman, Katherine Verdolini, Ivan Yotov, Ruben Zamora, and Sven Zenker. Additionally, several excellent technicians (Derek Barclay, David Gallo, and Binnie Betten) contributed to this work. We would also like to thank Alan Russell and Clifford Brubaker for their unwavering support. This work was supported in part by the National Institutes of Health grants R01-GM-67240, P50-GM-53789, R33-HL-089082, R01-HL080926, and R01-HL-76157; National Institute on Disability and Rehabilitation Research grant H133E070024; as well as grants from the Commonwealth of Pennsylvania, the Pittsburgh Lifesciences Greenhouse, and the Pittsburgh Tissue Engineering Initiative. Dr. Vodovotz is a cofounder of and consultant to Immunetrics, Inc., which has licensed from the University of Pittsburgh the rights to commercialize aspects of the mathematical modeling of inflammation. Dr. Vodovotz’s involvement with Immunetrics is monitored by the University of Pittsburgh’s Entrepreneurial Oversight Committee. Dr. An is also a consultant to Immunetrics, Inc.

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Authors and Affiliations

  1. Center for Inflammation and Regenerative Modeling, McGowan Institute of Regenerative Medicine and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Yoram Vodovotz

  2. Department of Surgery, Center for Inflammation and Regenerative Modeling, Northwestern University, Chicago, IL, USA

    Gary An

  3. McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Gary An

Authors
  1. Yoram Vodovotz
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  2. Gary An
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Corresponding author

Correspondence to Yoram Vodovotz .

Editor information

Editors and Affiliations

  1. PharmTao, Santa Clara, California, USA

    Qing Yan

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© 2010 Springer Science+Business Media, LLC

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Vodovotz, Y., An, G. (2010). Systems Biology and Inflammation. In: Yan, Q. (eds) Systems Biology in Drug Discovery and Development. Methods in Molecular Biology, vol 662. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-800-3_9

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  • DOI: https://doi.org/10.1007/978-1-60761-800-3_9

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-799-0

  • Online ISBN: 978-1-60761-800-3

  • eBook Packages: Springer Protocols

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