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Protein Misfolding and Cellular Stress in Disease and Aging pp 93–106Cite as

Mitophagy and Mitoptosis in Disease Processes

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 648))

Abstract

Mitochondria play a very important role in cellular function, not only through key metabolic reactions and energy generation, but also by being a major site for production of reactive oxygen species and a key player in cell death. Therefore, mitochondrial dysfunction or damage may have severe consequences. Mitophagy (autophagic degradation of mitochondria) and mitoptosis (programmed destruction of mitochondria) are the processes by which cells can deal with impaired mitochondria. The efficiency of these processes may be a contributing factor to the pathogenesis of various diseases.

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Acknowledgements

We apologise to investigators whose important original contributions have not been cited; where possible we have chosen to cite recent reviews in which details of such contributions can be found.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia

    Dalibor Mijaljica & Mark Prescott

  2. Department of Biochemistry and Molecular Biology and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC, Australia

    Rodney J. Devenish

Authors
  1. Dalibor Mijaljica
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  2. Mark Prescott
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  3. Rodney J. Devenish
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Corresponding author

Correspondence to Rodney J. Devenish .

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Editors and Affiliations

  1. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Peter Bross

  2. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Niels Gregersen

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Mijaljica, D., Prescott, M., Devenish, R.J. (2010). Mitophagy and Mitoptosis in Disease Processes. In: Bross, P., Gregersen, N. (eds) Protein Misfolding and Cellular Stress in Disease and Aging. Methods in Molecular Biology, vol 648. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-756-3_6

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  • DOI: https://doi.org/10.1007/978-1-60761-756-3_6

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-755-6

  • Online ISBN: 978-1-60761-756-3

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