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What Role Does Mitochondrial Stress Play in Neurodegenerative Diseases?

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Protein Misfolding and Cellular Stress in Disease and Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 648))

Abstract

The essential need for mitochondrial function has been extensively shown to relate to neuronal health. Neurodegeneration and neurodegeneration-related diseases have been associated with multiple mitochondrial dysfunctions. This review highlights key findings related to commonly studied mitochondrial dysfunctions: imbalance of mitochondrial dynamics, mutations in the mitochondrial genome, excessive reactive oxygen species, and misfolded protein associations/interactions with the mitochondria. Future research in mitochondrial function will help elucidate complex neurodegenerative events while impacting both individual and societal health.

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Authors and Affiliations

  1. The Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL, USA

    Alicia Mae Pickrell

  2. The Neuroscience Program and Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA

    Carlos Torres Moraes

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  1. Alicia Mae Pickrell
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  2. Carlos Torres Moraes
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Correspondence to Carlos Torres Moraes .

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  1. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Peter Bross

  2. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Niels Gregersen

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Pickrell, A.M., Moraes, C.T. (2010). What Role Does Mitochondrial Stress Play in Neurodegenerative Diseases?. In: Bross, P., Gregersen, N. (eds) Protein Misfolding and Cellular Stress in Disease and Aging. Methods in Molecular Biology, vol 648. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-756-3_4

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  • DOI: https://doi.org/10.1007/978-1-60761-756-3_4

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