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Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers

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Book cover Rodent Models of Stroke

Part of the book series: Neuromethods ((NM,volume 47))

Abstract

The quest for internal and external validity in experimental stroke research is fraught with pitfalls and confounders. This article, written as a checklist from the perspective of an editor and reviewer of articles on rodent stroke models and an active bench side stroke researcher, presents a compilation of the common pitfalls and quality issues in experimental stroke research. These include selecting controls for genetically modified animals, effects of stroke on systemic parameters (immunodepression, infection, cachexia, etc.), cerebral blood flow measurement, brain edema correction, study design, statistics and interpretation.

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Authors and Affiliations

  1. Department of Neurology and Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine Berlin, Berlin, Germany

    Ulrich Dirnagl

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  1. Ulrich Dirnagl
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Editors and Affiliations

  1. Charité Campus Mitte, Centrum für Schlaganfall-Forschung, Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10098, Germany

    Ulrich Dirnagl

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© 2010 Humana Press

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Dirnagl, U. (2010). Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 47. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-750-1_19

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  • DOI: https://doi.org/10.1007/978-1-60761-750-1_19

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-749-5

  • Online ISBN: 978-1-60761-750-1

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