Abstract
Non-invasive imaging technologies play a substantial role in the evaluation of physiological and pathophysiological processes. They are indispensable in biomedical research and in the clinic. In the past decade, designated small animal imaging scanners have become available for almost all imaging modalities used in clinical routine. These include nuclear imaging techniques such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), X-ray computed tomography (CT), and ultrasound (US). Among the imaging modalities used for small animal imaging, optical techniques such as fluorescence imaging (FI) and biolumnescence imaging (BLI) are becoming increasingly important. In this chapter, we describe the basic principles of optical imaging and the application of the techniques for the non-invasive visualization of biological processes in animal disease models, with special emphasis on small animal models of stroke.
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Acknowledgments
The authors would like to thank Prof. Dr. Ulrich Dirnagl, Center for Stroke Research (CSB), Department of Experimental Neurology, Charité – University Medicine Berlin, Germany for critical review of the manuscript, the valuable discussions about stroke imaging, and his continuous support.
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Wunder, A., Klohs, J. (2010). Non-invasive Optical Imaging in Small Animal Models of Stroke. In: Dirnagl, U. (eds) Rodent Models of Stroke. Neuromethods, vol 47. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-750-1_12
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DOI: https://doi.org/10.1007/978-1-60761-750-1_12
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