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Mass Spectrometry Imaging pp 405–413Cite as

Applications of MALDI-MSI to Pharmaceutical Research

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 656))

Abstract

MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections.

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Author information

Authors and Affiliations

  1. Analytical Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland

    Brendan Prideaux

  2. Novartis Institutes for BioMedical Research, Basel, Switzerland

    Dieter Staab & Markus Stoeckli

Authors
  1. Brendan Prideaux
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  2. Dieter Staab
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  3. Markus Stoeckli
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Editor information

Editors and Affiliations

  1. , Beckman Institute, Univ. of Illinois at Urbana-Champaign, N. Mathews Avenue 405, Urbana, 61801, Illinois, USA

    Stanislav S. Rubakhin

  2. , Department of Chemistry, Univ. of Illinois at Urbana-Champaign, South Mathews Avenue 63-5 600, Urbana, 61801, Illinois, USA

    Jonathan V. Sweedler

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Prideaux, B., Staab, D., Stoeckli, M. (2010). Applications of MALDI-MSI to Pharmaceutical Research. In: Rubakhin, S., Sweedler, J. (eds) Mass Spectrometry Imaging. Methods in Molecular Biology, vol 656. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-746-4_23

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  • DOI: https://doi.org/10.1007/978-1-60761-746-4_23

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-745-7

  • Online ISBN: 978-1-60761-746-4

  • eBook Packages: Springer Protocols

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