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Bifunctional Agents for Imaging and Therapy

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Photodynamic Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 635))

Abstract

Multiple, complementary techniques for tumor detection, including magnetic resonance, nuclear and optical imaging, are under active development; each approach has particular strengths and advantages. Efforts are also currently underway to develop bifunctional agents, so that a single molecule can be used for imaging, therapy, and monitoring the long-term tumor response. This chapter is mainly focused on illustrating the utility of certain tumor-avid photosensitizers in developing agents for tumor imaging [fluorescence, magnetic resonance imaging (MRI), positron emission tomography (PET)] and photodynamic therapy. Recent approaches for developing target-specific agents for photodynamic therapy (PDT) and in vivo tumor imaging are also briefly discussed.

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Acknowledgments

We are highly thankful to our collaborators over the years for their contributions. There name can be found in various citations. We also thank the NIH (CA55791, CA109914, CA114053, CA127639), Roswell Park Alliance, the Oncologic Foundation of Buffalo, and the shared resources of the RPCI (support Grant P30CA16056) for the financial support.

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Authors and Affiliations

  1. PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA

    Ravindra K. Pandey, Nadine S. James, Yihui Chen, Joseph Missert & Munawar Sajjad

  2. Department of Nuclear Chemistry, SUNY, Buffalo, NY, USA

    Yihui Chen & Munawar Sajjad

Authors
  1. Ravindra K. Pandey
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  2. Nadine S. James
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  3. Yihui Chen
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  4. Joseph Missert
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  5. Munawar Sajjad
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Editors and Affiliations

  1. Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Sunset Blvd. 4650, Los Angeles, 90027, California, USA

    Charles J. Gomer

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Pandey, R.K., James, N.S., Chen, Y., Missert, J., Sajjad, M. (2010). Bifunctional Agents for Imaging and Therapy. In: Gomer, C. (eds) Photodynamic Therapy. Methods in Molecular Biology, vol 635. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-697-9_16

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  • DOI: https://doi.org/10.1007/978-1-60761-697-9_16

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