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Genetic Animal Models of Anxiety

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Transgenic and Mutant Tools to Model Brain Disorders

Part of the book series: Neuromethods ((NM,volume 44))

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Abstract

Conditions such as generalized anxiety disorder, panic disorder, social phobia, specific phobia, obsessive-compulsive disorder, and post-traumatic stress disorder cause undue suffering and economic burden on a substantial portion of our society. The prevalence and serious debilitating effects of anxiety disorders increases the necessity for fast and efficacious understanding of the neurobiological pathways associated with these maladies. While the neural underpinnings of this spectrum may have been identified, further analysis is necessary to generate pharmacologically significant data. The development of new molecular genetics techniques applied towards the generation of specific knockout models with anxiety-like phenotypes have been instrumental to our understanding of anxiety spectrum disorders due to their specificity of effected targets. This chapter will discuss the individual anxiety spectrum disorders with a focus on the animal models displaying relevant phenotypes for neurobehavioral research.

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Supported by the NARSAD YI Award, Georgetown University Stress Physiology and Research Center (SPaRC), and Tulane University Intramural Research Funds.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC, USA

    Rupert J. Egan, Carisa L. Bergner & Justin L. LaPorte

  2. Department of Pharmacology, Tulane University Medical School, Tulane University, New Orleans, LA, USA

    Peter C. Hart & Allan V. Kalueff

Authors
  1. Rupert J. Egan
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  2. Carisa L. Bergner
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  3. Peter C. Hart
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  4. Justin L. LaPorte
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  5. Allan V. Kalueff
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Corresponding author

Correspondence to Allan V. Kalueff .

Editor information

Editors and Affiliations

  1. School of Medicine, Tulane University, Tulane Ave. 1430, New Orleans, 70112, U.S.A.

    Allan V. Kalueff

  2. E. Pittsburgh Ave. 235, Milwaukee, 53204, U.S.A.

    Carisa L. Bergner

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Egan, R.J., Bergner, C.L., Hart, P.C., LaPorte, J.L., Kalueff, A.V. (2010). Genetic Animal Models of Anxiety. In: Kalueff, A., Bergner, C. (eds) Transgenic and Mutant Tools to Model Brain Disorders. Neuromethods, vol 44. Humana Press. https://doi.org/10.1007/978-1-60761-474-6_9

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  • DOI: https://doi.org/10.1007/978-1-60761-474-6_9

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-473-9

  • Online ISBN: 978-1-60761-474-6

  • eBook Packages: Springer Protocols

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