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How T Cells Find Their Way Around

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T-Cell Trafficking

Part of the book series: Methods in Molecular Biology ((MIMB,volume 616))

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Abstract

Among diverse cellular systems of the body, the immune system is unique in representing a network of interacting cells of enormous complexity yet based on single cells travelling around. Only the advanced visualization technologies of the recent years have brought to everybody’s attention the fact that what we see is usually a snapshot of a dynamic system, where the majority of players are highly motile and become coordinated by diverse signals provided by their environment. This introductory chapter touches a selection of aspects that address predominantly the functioning of the system as such. It attempts to provide a framework of how migratory mechanisms are regulated to ensure that various cell populations reach their destination and that the appropriate interaction partners find each other.

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Acknowledgments

Special thanks to present and past coworkers of my group who contributed to ideas and findings discussed above: G. Debes, C. Doebis, S. Floess, S. Ghani, J. Huehn, S. Jennrich, A. Menning, B. Ratsch, K. Siegmund, C. Siewert, U. Syrbe, and B. Szilagyi. Our work was continuously supported by the Deutsche Forschungsgemeinschaft.

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Authors and Affiliations

  1. Experimentelle Rheumatologie, CC12, Charité Universitätsmedizin Berlin, Berlin, Germany

    Alf Hamann

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  1. Alf Hamann
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Editors and Affiliations

  1. Hammersmith Hospital, Dept. Immunology, Imperial College London, Du Cane Road, London, W12 0NN, United Kingdom

    Federica M. Marelli-Berg

  2. School of Medicine and Dentistry, William Harvey Research Inst., Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Sussan Nourshargh

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Hamann, A. (2010). How T Cells Find Their Way Around. In: Marelli-Berg, F., Nourshargh, S. (eds) T-Cell Trafficking. Methods in Molecular Biology, vol 616. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-461-6_1

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  • DOI: https://doi.org/10.1007/978-1-60761-461-6_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-460-9

  • Online ISBN: 978-1-60761-461-6

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