Abstract
Ketamine hydrochloride, a Schedule III drug under the Controlled Substances Act, is a dissociative anesthetic that has a combination of stimulant, depressant, hallucinogenic, and analgesic properties. This procedure utilizes solid phase extraction of blood, tissue, or urine samples to isolate ketamine (special K) and its metabolite norketamine. The extract is then assayed using selected ion monitoring gas chromatography/mass spectrometry for absolute structural confirmation of the compound and the compounds quantified by comparing responses of the unknown samples to the responses of standards.
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References
Baselt, R. C. (2000) Disposition of Toxic Drugs and Chemicals in Man, 5th ed. Chem. Tox. Inst., pp. 456–458.
Moffatt, A. C., Osselton, M. D. and Widdop, B. (2004) Clarke’s Analysis of Drugs and Poisons, 3rd ed. Pharm Press, pp. 1152–1153.
Drug-Facilitated Sexual Assault Resource Guide. 2003-R0502-001. NDIC and George Mason University, pp. 9–11, May 2003.
Applications Manual (1991) CLEAN SCREEN Extraction Column. Worldwide Monitoring Corp. Horsham, PA.
Trace Application Manual; SPEware Corporation; San Pedro, CA (2004).
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Rohrig, T.P., Gamble, M., Cox, K. (2010). Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS). In: Garg, U., Hammett-Stabler, C. (eds) Clinical Applications of Mass Spectrometry. Methods in Molecular Biology, vol 603. Humana Press. https://doi.org/10.1007/978-1-60761-459-3_30
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DOI: https://doi.org/10.1007/978-1-60761-459-3_30
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