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Immunotoxicity Testing pp 75–94Cite as

Evaluating Macrophages in Immunotoxicity Testing

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 598))

Abstract

Macrophages are the heterogeneous grouping of cells that are derived from monocytes. They have a multitude of functions depending on their final differentiated state. These functions range from phagocytosis to antigen presentation to bone destruction, to name a few. Their importance in both the innate and acquired immune functions is undeniable. Xenobiotics that degrade their functional status can have grave consequences. In this chapter, we provide an overview of the types of macrophages, their hematopoietic origin and a general discussion of the many different assays that are used to assess their functional status.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA

    John B. Barnett & Kathleen M. Brundage

Authors
  1. John B. Barnett
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  2. Kathleen M. Brundage
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Corresponding author

Correspondence to John B. Barnett .

Editor information

Editors and Affiliations

  1. College of Veterinary Medicine, Cornell University, Ithaca, 14853, U.S.A.

    Rodney R. Dietert

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Barnett, J.B., Brundage, K.M. (2010). Evaluating Macrophages in Immunotoxicity Testing. In: Dietert, R. (eds) Immunotoxicity Testing. Methods in Molecular Biology™, vol 598. Humana Press. https://doi.org/10.1007/978-1-60761-401-2_6

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  • DOI: https://doi.org/10.1007/978-1-60761-401-2_6

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-400-5

  • Online ISBN: 978-1-60761-401-2

  • eBook Packages: Springer Protocols

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