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Immunotoxicity Testing pp 17–25Cite as

Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 598))

Abstract

Developmental immunotoxicity (DIT) has emerged as a serious health consideration given the increases in the prevalence of many immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes. As a result, the use of DIT testing to identify potential environmental risk factors contributing to these and other diseases has become a higher priority. This introductory chapter considers: (1) the basis for an increased and earlier use of DIT testing in safety evaluations and (2) the general features of DIT testing strategies designed to reduce health risks.

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Acknowledgments

The authors thank Janice Dietert for her editorial assistance.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

    Jamie DeWitt

  2. Department of Phamacology and Toxicology, East Carolina University, Greenville, NC, USA

    Rodney R. Dietert

Authors
  1. Rodney R. Dietert
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  2. Jamie DeWitt
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Corresponding author

Correspondence to Rodney R. Dietert .

Editor information

Editors and Affiliations

  1. College of Veterinary Medicine, Cornell University, Ithaca, 14853, U.S.A.

    Rodney R. Dietert

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Dietert, R.R., DeWitt, J. (2010). Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing. In: Dietert, R. (eds) Immunotoxicity Testing. Methods in Molecular Biology™, vol 598. Humana Press. https://doi.org/10.1007/978-1-60761-401-2_2

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  • DOI: https://doi.org/10.1007/978-1-60761-401-2_2

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-400-5

  • Online ISBN: 978-1-60761-401-2

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