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Natural Killer Cell Protocols pp 97–126Cite as

Studying NK Cell/Dendritic Cell Interactions

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 612))

Abstract

Although NK cells were originally identified as “naturally” active cells believed to follow a cell-autonomous activation program, it is now widely accepted that NK cells need to interact with dendritic cells for their full functional activation and for their homeostasis. In this chapter, we will provide an experimental guide to the analysis of NK cell/DC interactions in vitro and in vivo. We have put special emphasis on the recently developed mouse models allowing the inducible and specific ablation of various subsets of DCs and other myeloid cells.

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Authors and Affiliations

  1. Institute of Medical Microbiology & Hygiene, University of Freiburg Medical Center, Freiburg, Germany

    Mathias Lucas, Cedric Vonarbourg, Peter Aichele & Andreas Diefenbach

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  1. Mathias Lucas
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  2. Cedric Vonarbourg
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  3. Peter Aichele
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  4. Andreas Diefenbach
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Editors and Affiliations

  1. Institute for Cancer Research, Fox Chase Cancer Center, Cottman Avenue 333, Philadelphia, 19111-2497, U.S.A.

    Kerry S. Campbell

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Lucas, M., Vonarbourg, C., Aichele, P., Diefenbach, A. (2010). Studying NK Cell/Dendritic Cell Interactions. In: Campbell, K. (eds) Natural Killer Cell Protocols. Methods in Molecular Biology, vol 612. Humana Press. https://doi.org/10.1007/978-1-60761-362-6_8

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  • DOI: https://doi.org/10.1007/978-1-60761-362-6_8

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