Summary
The primary function of HIV-1 binding to its chemokine coreceptors is to mediate fusion and viral entry. However, it has been known that this interaction also triggers a variety of signaling cascades. It is likely that the virus-mediated signaling events may facilitate viral infection in various settings where the cellular conditions need to be primed. This has been exemplified recently in our findings that HIV-1 employs envelope-CXCR4 interaction to activate a cellular actin depolymerization factor, cofilin, to support viral latent infection of resting CD4 T cells. Activation of cofilin promotes the cortical actin dynamics that are critical for viral intracellular migration across the static cortical actin barrier in resting T cells.
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Acknowledgment
This work was supported by the Public Health Service grant AI069981 from NIAID to Y.W.
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© 2009 Humana Press
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Wu, Y. (2009). Chemokine Receptor Signaling and HIV Infection. In: Jin, T., Hereld, D. (eds) Chemotaxis. Methods in Molecular Biology™, vol 571. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-198-1_21
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DOI: https://doi.org/10.1007/978-1-60761-198-1_21
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