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miRNAs: From Biogenesis to Networks

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Protein Networks and Pathway Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 563))

Abstract

In eukaryotes, besides alternative splicing and promoter regulation of “classical” genes, there is also another level of genetic regulation based on non-coding RNAs (ncRNAs). The most famous group of ncRNAs is microRNAs, probably the biggest number of genome regulators. Here, we summarize the knowledge that has been accumulated about the microRNA field, focusing our attention on brief history, biogenesis, regulated mechanism, computational methods of miRNA finding and miRNA target sites, miRNAs and diseases, and miRNAs and network analysis.

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Acknowledgments

We would like to thank all colleagues who have done studies in this field. We apologize to the colleagues whose work in this rapidly changing field was not directly cited in this chapter due to space limitations and timing. G.R. acknowledges the members of GeneGo Inc. (Drs Laura Brovold, Julie Bryant, John Metz, and Yuri Nikolsky) for their useful assistance and invaluable time. This work is supported by NIH grants (A.G.) and the Sbarro Health Research Organization (A.G. and G.R.).

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  1. Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA

    Giuseppe Russo & Antonio Giordano

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  1. Giuseppe Russo
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  2. Antonio Giordano
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Editors and Affiliations

  1. GeneGo Inc., Saxony Road 169, Encinitas, 92024, U.S.A.

    Yuri Nikolsky

  2. GeneGo Inc., Saxony Road 169, Encinitas, 92024, U.S.A.

    Julie Bryant

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Russo, G., Giordano, A. (2009). miRNAs: From Biogenesis to Networks. In: Nikolsky, Y., Bryant, J. (eds) Protein Networks and Pathway Analysis. Methods in Molecular Biology, vol 563. Humana Press. https://doi.org/10.1007/978-1-60761-175-2_17

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