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Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening

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Mouse Models for Drug Discovery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 602))

Abstract

A large variety of mouse models for human skin and adnexa diseases are readily available from investigators and vendors worldwide. While the skin is an obvious organ to observe lesions and their response to therapy, actually treating and monitoring progress in mice can be challenging. This chapter provides an overview on how to use the laboratory mouse as a preclinical tool to evaluate efficacy of a new compound or test potential new uses for a compound approved for use for treating an unrelated disease. Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented.

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Acknowledgments

This work was supported by grants from the National Alopecia Areata Foundation (NAAF).

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Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, ME, USA

    John P. Sundberg, Kathleen A. Silva & Caroline McPhee

  2. Department of Medicine, Division of Dermatology, The Skin Disease Research Center, Vanderbilt Medical Center, Nashville, TN, USA

    John P. Sundberg & Lloyd E. King JR

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  1. John P. Sundberg
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  2. Kathleen A. Silva
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  3. Caroline McPhee
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  4. Lloyd E. King JR
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Editors and Affiliations

  1. The Jackson Laboratory, Main Street 600, Bar Harbor, 04609, Maine, USA

    Gabriele Proetzel

  2. Jackson Laboratory, Main Street 600, Bar Harbor, 04609, USA

    Michael V. Wiles

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Sundberg, J.P., Silva, K.A., McPhee, C., King, L.E. (2010). Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 602. Humana Press. https://doi.org/10.1007/978-1-60761-058-8_12

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