Abstract
Cancer of the breast is a significant health problem for women from the time of diagnosis through the treatment and survivorship trajectory. The disease and treatments are an assault to a woman's body, resulting in sequelae that can be debilitating. Although women diagnosed with breast cancer are living longer, concerns about functional limitations, recurrence, and survival remain paramount. Physical activity and exercise are preventative and rehabilitative measures that can be employed at various points along the breast cancer trajectory. Current research supports the beneficial role that physical activity and exercise play in reducing the risk for developing breast cancer and preventing or attenuating disease and treatment-related impairments.
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References
American Cancer Society. (2008) Cancer facts and figures 2008. Atlanta, GA.
Ravdin, P.M., Cronin, KA., Howlader, N., Berg, C.D. (2007) The decrease in breast-cancer incidence in 2003 in the United States. N Engl J Med 356 , 1670 –1674.
Nelson, H. D., Humphrey, L.L., Nygren, P., Teutsch, S.M., Allan, J.D. (2002) Post-menopausal hormone replacement therapy. JAMA 288 , 872 – 891.
Ozols, R. F., Herbst, R.S., Colson, U.L., Gralow, J., Bonner, J., Curran, W.J. Jr., et al. (2007) Clinical cancer advances 2006: Major research advances in cancer treatment, prevention and screening — a report from the American Society of Clinical Oncology. J Clin Onc 25 , 146 – 162.
Berry, D.A., Cronin, K.A., Plevritis, S.K., et al. (2005) Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 353 , 1784 – 1792.
National Cancer Institute. A snapshot of breast cancer. September, 2006. Retrieved July 23, 2007 from http://planning.cancer gov/disease/Breast-Snapshot.pdf.
Li, C.I., Malone, K.E., Daling, J.R. (2003) Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch Intern Med 163 , 49 – 56.
National Cancer Institute. Fact sheet: Probability of breast cancer in American women. October 5, 2006 Retrieved July 23, 2007 from http://www.cancer.gov/images/Documents/bd21295f-31fa-419b-b249-54311ca969a1/fs5_6.pdf.
Kruk, J. (2007) Lifetime physical activity and the risk of breast cancer: A case-control study. Cancer Detect Prev 31 , 19 – 28.
McTiernan, A., Kooperberg, C., White, E., Wilcox, S., Coates, R., Adams-Campbell, L.L., Woods, N., Ockene, J. (2003) Recreational physical activity and the risk of breast cancer in postmenopausal women: The Women's Health Initiative cohort study. JAMA 290 , 1331 – 1336.
US Department of Health and Human Services. (1966) Physical activity and health: a report of the Surgeon General. Atlanta: Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion.
Nagi, S.Z. (1965). Some conceptual issues in disability and rehabilitation. In M. B. Sussman (Ed.), Sociology and Rehabilitation (pp. 100 – 13). Washington, DC: American Sociological Association.
Pope, A.M., Tarlov, A.R. (Eds.) (1991) Disability in America: Toward a national agenda for prevention. Washington, DC: National Academy Press.
Reigle, B.S. (2006) The prevention of disablement: A framework for the breast cancer trajectory. Rehab Nurs 31, 174–179.
Bosompra, K., Ashikaga, T., O'Brien, P.J., Nelson, L., Skelly, J. (2002) Swelling, numbness, pain, and their relationship to arm function among breast cancer survivors: A disablement process model perspective. Breast J 8, 338–348.
Mock, V., Pickett, M., Ropka, M.E., Lin, E.M., Stewart, K.J., Rhodes, V.A., et al. (2001) Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Prac 9, 119–127.
Bender, C.M., McDaniel, R.W., Murphy-Ende, K., Pickett, M., Rittenberg, C.N., Rogeres, M.P., et al. (2002) Chemotherapy-induced nausea and vomiting. Clin J Oncol Nurs 6, 94–102.
Pinto, B.M., Clark, M.M., Maruyama, N.C., Feder, S.I. (2003) Psychological and fitness changes associated with exercise participation among women with breast cancer. Psychooncology 12, 118–126.
Silverman, D.H.S., Dy, C.J., Castellon, S.A., Lai, J., Pio, B., Abraham, L., et al. (2007) Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5 – 10 years after chemotherapy. Breast Cancer Res Treat 103, 303–311.
Hutnick, N. A., Williams, N.I., Kraemer, W.J., Orsega-Smith, E., Dixon, R.H., Bleznak, A.D., Mastro, A.M. (2005) Exercise and lymphocyte activation following chemotherapy for breast cancer. Med Sci Sports Exerc 37, 1827–1835.
Mizuno, T., Katsumata, N., Mukai, H., Shimizu, C., Ando, M., Watanabe, T. (2007) The outpatient management of low-risk febrile patients with neutropenia: risk assessment over the telephone. Support Care Cancer 15, 287–291.
Brady, M.J., Cella, D.F., Mo, F., Bonomi, A.E., Tulsky, D.S., Lloyd, S.R., et al. (1997) Reliability and validity of the functional assessment of cancer therapy-breast quality-of-life instrument. J Clin Oncol 15, 974–986.
Kolden, G.G., Strauman, T.J., Ward, A., et al. (2002) A pilot study of group exercise training (GET) for women with primary breast cancer: Feasibility and health benefits. Psychooncology 11,447–456.
Darga, L.L., Megnan, M., Mood, D., Hryniuk, W.M., DiLaura, N.M., Djuric, Z. (2007) Quality of life as a predictor of weight loss in obese, early-stage breast cancer survivors. Oncol Nurs Forum 34, 86–92.
Freidenreich, C.M., Orenstein, M.R. (2002) Physical activity and cancer prevention: Etiologic evidence and biological mechanisms. J Nutr 132, 3456S–3464S.
Frisch, R.E., Wyshak, G., Albright, N.L., et al. (1985) Lower prevalence of breast cancer and cancers of reproductive system among former college athletes compared to nonathletes. Br J Cancer 52, 885–891.
Bernstein, L., Henderson, B.E., Hanisch, R., et al. (1994) Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 86, 1403–1408.
Matthews, C.E., Fowke, J.H., Dai, Q., et al. (2004) Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control 15, 473–481.
Friedenreich, C.M., Thune, I., Brinton, L.A., et al. (1998) Epidemiologic issues related to the association between physical activity and breast cancer. Cancer 83, 600–610.
Gammon, M.E., John, E.M., Britton, J.A. (1998) Recreational and occupational physical activities and risk of breast cancer. J Natl Cancer Inst 90, 100–117.
Friedenreich, C.M.. (2001) Physical activity and cancer prevention from observational to intervention research. Cancer Epidemiol Biomarkers Prev 10, 287–301.
Gammon, M.D., Schoenberg, J.B., Britton, J.A., et al. (1998) Recreational physical activity and breast cancer risk among women under 45 years. Am J Epidemiol 147, 273–280.
Moore, D.B., Folsom, A.R., Mink, P.J., et al. (2000) Physical activity and incidence of postmenopausal breast cancer. Epidemiol 2000 11, 292–296.
Carpenter, C.L., Ross, R.K., Panganini-Hill, A., et al. (1999) Lifetime exercise activity and breast cancer risk among post-menopausal women. Br J Cancer 80, 1852–1858.
Friedenreich, C.M., Bryant, H.E., Courneya, K.S. (2001) Case-control study of lifetime physical activity and breast cancer risk. Am J Epidemiol 154, 336–347.
Young, D., Bernstein, L., Wu, A.H. (2003) Physical activity and breast cancer. Cancer 97, 2565–2575.
Rockhill B., Willett, W.C., Hunter, D.J., et al. (1999) A prospective study of recreational physical activity and breast cancer risk. Arch Intern Med 159, 2290–2296.
Broocks, A., Pirke, K.M., Schweiger, U., et al. (1990) Cyclic ovarian function in recreational athletes. J Appl Physiol 68, 2083–2086.
Russell, J.B., Mitchell, D., Musey, P.I., et al. (1984) The relationship of exercise to anovulatory cycles in female athletes: Hormonal and physical characteristics. Obstet Gynecol 63, 452–456.
McTiernan, A., Kooperberg, C., White, E., et al. (2003) Is exercise effective in reducing the risk of breast cancer in postmenopausal women? JAMA 290, 1331–1336.
Gauley, J.A., Gutai, J.P., Kuller, L.H., et al. (1989) The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 129, 1120–1131.
Cadenas, E., Davies, K.J. (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29, 222–230.
Kanter, M.M., Hamlin, R.L., Unverferth, D.V., et al. (1985) Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin. J Appl Physiol 59, 1298–1303.
Minotti, G., Cairo, G., Monti, E. (1999) Role of iron in anthracycline cardiotoxicity: new tunes for an old song? FASEB J 13, 199–212.
Yu, B.P. (1994) Cellular defenses against damage from reactive oxygen species. Physiol Rev 74, 139–162.
Nakao, C., Ookawara, T., Kizaki, T., et al. (2000) Effects of swimming training on three superoxide dismutase isoenzymes in mouse tissues. J Appl Physiol 88, 649–654.
Meister, A., Anderson, M. E. (1983) Glutathione. Annu Rev Biochem 52, 711–760.
Abraham, R., Basser, R.L., Green, M.D. (1996) A risk-benefit assessment of anthra-cycline antibiotics in antineoplastic therapy. Drug Saf 15, 406–429.
Wencker, D., Chandra, M., Nguyen, K., (2003) A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 111, 1497–1504.
Afford, S., Randhawa, S. (2000) Apoptosis. Am J Clinical Pathol 53, 55–63.
Kalyanaranam, B., Joseph, J., Kalivendi, S., et al. (2002) Doxorubicin-induced apoptosis implications in cardiotoxicity. Mol Cell Biochem 234, 119–124.
Primeau, A.J., Adhihetty, P.J., Hood, D.A. (2002) Apoptosis in heart and skeletal muscle. Can J Appl Physiol 27, 349–395.
Green, P.S., Leeuwenburg, C. (2002) Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis. Biochimica et Biophysica Acta 1588, 94–101.
Li, P., Nijhawan, D., Budihardjo, I., et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479–489.
Nomura, K. Imai, H., Koumura, T., et al. (1999) Mitochondrial phospholipids hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J Biol Chem 274, 29294–29302.
Wang, X., Martindale, J.L., Liu, Y., et al. (1998) The cellular response to oxidative stress: influences of mitogen-activiated protein kinase signaling pathways on cell survival. Biochem J 333, 291–300.
Radak, Z,. Gaal, D., Taylor, A.W., et al. (2002) Attenuation of the development of murine solid leukemia tumor by physical exercise. Antioxid Redox Signal 4, 213–219.
Ries, L.A.G., Eisner, M.P., Kosary, C. L., Hankey, B. F., Miller, B.A., Clegg, L., et al. (Eds.). (2004) SEER cancer statistics review, 1975–2001, Bethesda, MD, NCI http://seer.cancer.gov/csr/1975_2001/.
Courneya, K.S., Mackey, J.R., McKenzie, D.C. (2002) Exercise for breast cancer survivors. Physic Sportsmed 30, 1–12.
National Cancer Institute Breast cancer (PDQ): Treatment health professional version. Retrieved July 22, 2007 from http://www.cancer.gov/cancertoics/pdq/treatment/breast/healthprofessional/.
American Cancer Society. (2003) Breast cancer facts and figures 2003 – 2004. Atlanta, GA: American Cancer Society.
National Comprehensive Cancer Network and American Cancer Society. (2006) Breast cancer: Treatment guidelines for patients. Atlanta, GA: American Cancer Society.
Bender, C.M., McDaniel, R.W., Murphy-Ende, K., Pickett, M., Rittenberg, C.N., Rogeres, M.P., et al. (2002). Chemotherapy-induced nausea and vomiting. Clin J Oncol Nurs 6, 94–102.
Batchelor, D. (2001) Hair and cancer chemotherapy: Consequences and nursing care — a literature study. Eur J Cancer Care 10, 147–163.
Dimeo, F.C. (2001) Effects of exercise on cancer-related fatigue. Cancer 92, 1689–1693.
Kattlove, H., Winn, R.J. (2003) Ongoing care of patients after primary treatment for cancer. Ca Cancer J Clin 54, 172–196.
Aziz, N.M. (2002) Cancer survivorship research: Challenge and opportunity. J Nutr 132, 3494S–3503S.
Winick, L., Robbins, G.F. (1977) Physical and psychologic readjustment after mastectomy. Cancer 39, 478–486.
Pinto, B.M., Clark, M.M., Maruyama, N.C., Feder, S.I. (2003) Psychological and fitness changes associated with exercise participation among women with breast cancer. Psychooncology 12, 118–126.
Lash, T.L., Silliman, R.A. (2000) Patient characteristics and treatments associated with a decline in upper-body function following breast cancer therapy. J Clinl Epidemiol 53, 615–622.
Satariano, W.A., Ragland, D.R., DeLorenze, G.N. (1996) Limitations in upper-body strength associated with breast cancer: A comparison of black and white women. J Clin Epidemiol 49, 535–544.
Box, R.C., Reul-Hirche, H.M., Bullock-Saxton, J.E., Furnival, C.M. (2002) Shoulder movement after breast cancer surgery: Results of a randomized controlled study of postoperative physiotherapy. Breast Cancer Res Treat 75, 35–50.
Brown, J.R. (2004) A clinically useful method for evaluating lymphedema. Clin J Oncol Nurs 8, 35–38.
Pasket, E.D., Stark, N. (2000) Lymphedema: Knowledge, treatment, and impact among breast cancer survivors. Breast J 6, 373–378.
Miller, L.T. (2002). Management of breast cancer-related edemas. In Macken, E.J., Callahan, A.D., Osterman, A.L., Skirven, T.M., Schneider, L.H., Hunter, J.M., eds. Rehablitiation of the Hand and Upper Extremity. St. Louis, MO: Mosby, 914–928.
Holmes, M.D., Kroenke, C.H. (2004) Beyond treatment: Lifestyle choices after breast cancer to enhance quality of life and survival. Women's Health Issues 14, 11–13.
Fogelman, I., Blake, G.M., Blamey, R., Palmer, M., Sauerbrei, W., Schumacher, M., et al. (2003) Bone mineral density in premenopausal women treated for node-positive early breast cancer with 2 years of goserelin or 6 months of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). Osteoporos Int 14, 1001–1006.
Shimozuma, K., Ganz, P.A., Petersen, L., Hirji, K. (1999) Quality of life in the first year after breast cancer surgery: Rehabilitation needs and patterns of recovery. Breast Cancer Res Treat 56, 45057.
Harris, S.R., Campbell, K.L., McNeely, M.L. (2005) Upper extremity rehabilitation for women who have been treated for breast cancer. Physiother Can 56, 202–214.
Rietman, J.S., Kijkstra, P.U., Geertzen, J.H.B., Baas, P., de Vries, J., Dolsma, W., et al. (2003) Short-term morbidity of the upper limb after sentinel lymph node biopsy or axillary lymph node dissection for stage I or II breast carcinoma. Cancer 98, 690–696.
Baron, R.H, Fey, J.V., Borgen, P.I., et al. (2004) Eighteen sensations after breast cancer surgery: A two-year comparison of sentinel lymph node biopsy and axillary lymph node dissection. Oncol Nurs Forum 31, 691–698.
Luini, A., Galimberti, V., Gati, G., Arnone, P., et al. (2005) The sentinel node biopsy after previous breast surgery: Preliminary results on 543 patients treated at the European Institute of Oncology. Breast Cancer Res Treat 89, 159–163.
Ververs, J.M.M.A., Roumen, R.M.H., Vingerhoets, A.J.J.M., Vreugdenhil, G., Coebergh, J.W.W., Crommelin, M.A., et al. (2001) Risk, severity and predictors of physical and psychological morbidity after axillary lymph node dissection for breast cancer. Eur J Cancer 37, 991–999.
Harris, S.R., Niesen-Vertommen, S.L. (2000) Challenging the myth of exercise-induced lymphedema following breast cancer: A series of case reports. J Surg Oncol 74, 95–99.
Lane, K., Jespersen, D., McKenzie, D.C. (2005) The effect of a whole body exercise programme and dragon boat training on arm volume and arm circumference in women treated for breast cancer. Eur J Cancer Care 14, 353–358.
Holleb, A.I. (1990) Two decades of Reach to Recovery: A tribute to the volunteers. CA Cancer J Clin 40, 5–7.
Shamley, D.R., Barker, K., Simonite, V., Beardshaw, A. (2005) Delayed versus immediate exercises following surgery for breast cancer: A systematic review. Breast Cancer Res Treat 90, 263–271.
Na,Y.M., Lee, J.S., Park, J.S., Kang, S.W., Lee, H.D., Koo, J.Y. (1999) Early rehabilitation program in postmastectomy patients: A prospective clinical trial. Yonsei Med J 40, 1–8.
Wingate, L. (1985) Efficacy of physical therapy for patients who have undergone mastectomies: A prospective study. Phys Ther 65, 896–900.
Kirshbaum, M.N. (2006) A review of the benefits of whole body exercise during and after treatment for breast cancer. J Clin Nurs 16, 104–121.
Headley, J.A, Ownby, K., John, L.D. (2004) The effect of seated exercise on fatigue and quality of life in women with advanced breast cancer. Oncol Nurs Forum 31, 977–983.
Lee, T.S., Kilbreath, S.L., Refshauge, K.M., Pendlebur y, S.C., Beith, J.M., Lee, M .J. (2007) Pectoral stretching program for women undergoing radiotherapy for breast cancer. Breast Cancer Res Treat 102, 313–321.
Matthew, C.E., Wilcox, S., Hanby, C.L., Ananian, C.D., Heiney, S.P., Gebretsadik, T., et al. (2007) Evaluation of a 12-week home-based walking intervention for breast cancer survivors. Support Care Cancer 15, 203–211.
Ohira, T., Schmitz, K.H, Ahmed, R.L., Ye, D. (2006) Effects of weight training on quality of life in recent breast cancer survivors. Cancer 106, 2076–2083.
Holmes, M.D., Chen, W.Y., Feskanich, D., Kroenke, C.H., Colditz, G.A. (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293, 2479–2486.
Denmark-Wahnefried, W., Pinto, B.M., Gritz, E.R. (2006) Promoting health and physical function among cancer survivors: Potential for prevention and questions that remain. J Clin Oncol 24, 5125–5131.
Kushi, L.H., Kwan, M.I., Lee, M.M., Ambrosone, C.B. (2007) Lifestyle factors and survival in women with breast cancer. J Nutr 137, 236S–242S.
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Reigle, B.S., Wonders, K. (2009). Breast Cancer and the Role of Exercise in Women. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 472. Humana Press. https://doi.org/10.1007/978-1-60327-492-0_7
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DOI: https://doi.org/10.1007/978-1-60327-492-0_7
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