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Genetic Polymorphisms in the Transforming Growth Factor-β Signaling Pathways and Breast Cancer Risk and Survival

  • Protocol
Cancer Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 472))

Abstract

The transforming growth factor (TGF)-β signaling pathway plays a critical role in breast cancer development and progression. Limited data from human studies, however, are currently available to link biomarkers in this pathway directly to the risk and survival of breast cancer. Most of the previous epidemiologic studies have focused on evaluating polymorphisms in the TGFB1 gene (T+29C, rs1982073) and the TGFBR1 gene (9A/6A), and the results have been inconsistent. The present review summarizes epidemiologic evidence regarding the association of genetic polymorphisms in the TGF β pathway genes with breast cancer risk and survival and provides rationale and new approaches to continuing the research in this area.

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Authors and Affiliations

  1. Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA

    Wei Zheng

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  1. Wei Zheng
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Editors and Affiliations

  1. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Zheng, W. (2009). Genetic Polymorphisms in the Transforming Growth Factor-β Signaling Pathways and Breast Cancer Risk and Survival. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 472. Humana Press. https://doi.org/10.1007/978-1-60327-492-0_11

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  • DOI: https://doi.org/10.1007/978-1-60327-492-0_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-491-3

  • Online ISBN: 978-1-60327-492-0

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