Transplantation of Avian Neural Tissue

  • Sarah Guthrie
Part of the METHODS IN MOLECULAR BIOLOGY™ book series (MIMB, volume 461)

1. Introduction

The transplantation of neural tissue provides a means of addressing many questions in developmental neurobiology and regeneration of the nervous system. Although this technique has been used in fish, amphibia, avian, and mammalian species, this chapter focuses on neural transplantation in avia, which has several advantages. The development of the nervous system provides a close parallel to that of mammalian embryos in many of its aspects, and embryos can be accessed at developmental stages impossible in mammals. In addition, avian eggs can be obtained at low cost, and minimal equipment and facilities are required for these types of grafting experiments. Transplantation is possible at both the cranial and spinal levels of the neuraxis, but the accessibility of these regions varies with stage. For example, transplantation of brain regions (e.g., (1)) is relatively easy at stages in which the neural tube has yet to develop the local expansions of the brain vesicles and has...


Neural Tube Neural Tissue Tissue Piece Vitelline Membrane Donor Embryo 
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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Sarah Guthrie
    • 1
  1. 1.MRC Centre for Developmental NeurobiologyKing's College LondonLondonUK

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