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The Classification of Protein Domains

  • Protocol
Bioinformatics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 453))

Abstract

The significant expansion in protein sequence and structure data that we are now witnessing brings with it a pressing need to bring order to the protein world. Such order enables us to gain insights into the evolution of proteins, their function, and the extent to which the functional repertoire can vary across the three kingdoms of life. This has led to the creation of a wide range of protein family classifications that aim to group proteins based on their evolutionary relationships.

This chapter discusses the approaches and methods that are frequently used in the classification of proteins, with a specific emphasis on the classification of protein domains. The construction of both domain sequence and domain structure databases is considered and the chapter shows how the use of domain family annotations to assign structural and functional information is enhancing our understanding of genomes.

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Author information

Authors and Affiliations

  1. Biochemistry and Molecular Biology Department, University College London, London, United Kingdom

    Russell L. Marsden & Christine A. Orengo

Authors
  1. Russell L. Marsden
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  2. Christine A. Orengo
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Editor information

Editors and Affiliations

  1. School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

    Jonathan M. Keith PhD

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Marsden, R.L., Orengo, C.A. (2008). The Classification of Protein Domains. In: Keith, J.M. (eds) Bioinformatics. Methods in Molecular Biology™, vol 453. Humana Press. https://doi.org/10.1007/978-1-60327-429-6_5

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  • DOI: https://doi.org/10.1007/978-1-60327-429-6_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-428-9

  • Online ISBN: 978-1-60327-429-6

  • eBook Packages: Springer Protocols

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