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Liquid Chromatography In Clinical Analysis pp 253–305Cite as

Determination of Tyrosine and Tryptophan Metabolites in Body Ruids Using Electrochemical Detection

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Part of the book series: Biological Methods ((BM))

Abstract

The amino acids tyrosine and tryptophan are precursors for a number of important physiological compounds. The catecholamines, which are metabolites of tyrosine, serve as neurotransmitters in the central and peripheral nervous systems. Serotonin, a major metabolite of tryptophan, is a potent neurotransmitter and vasoconstrictor. Without doubt, these compounds have been some of the most intensely studied molecules in the last twenty years. One of the benefits that often accrues from basic biochemical research is clinical data of diagnostic and prognostic significance. In this case, however, the results have been disappointing. In only a few instances has the measurement of metabolites of these two amino acids been shown to have real clinical significance.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Purdue University, West Lafayette, Indiana

    Gregory C. Davis (Research Chemist), David D. Koch (Research Associate) & Peter T. Kissinger

  2. Monsanto Agricultural Research Center, St. Louis, Missouri

    Gregory C. Davis (Research Chemist)

  3. Clinical Chemistry Laboratories, Barnes, Hospital, St. Louis, Missouri

    David D. Koch (Research Associate)

  4. Research Laboratory, Bioanalytical Systems, West Lafayette, Indiana

    Craig S. Bruntlett & Ronald E. Shoup

Authors
  1. Gregory C. Davis
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  2. David D. Koch
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  3. Peter T. Kissinger
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  4. Craig S. Bruntlett
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  5. Ronald E. Shoup
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Editor information

Editors and Affiliations

  1. University of California School of Medicine, San Francisco, California

    Pokar M. Kabra  & Laurence J. Marton  & 

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Davis, G.C., Koch, D.D., Kissinger, P.T., Bruntlett, C.S., Shoup, R.E. (1981). Determination of Tyrosine and Tryptophan Metabolites in Body Ruids Using Electrochemical Detection. In: Kabra, P.M., Marton, L.J. (eds) Liquid Chromatography In Clinical Analysis. Biological Methods. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-404-3_12

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  • DOI: https://doi.org/10.1007/978-1-60327-404-3_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-026-8

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