Skip to main content

In Vitro and Cell Culture Analysis of Metal Carcinogenesis

  • Protocol
Metal Carcinogenesis Testing

Part of the book series: Biological Methods ((BM))

  • 169 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Eichorn, G. L., C. Richardson, and J. Pitha, Mispairing of nucleotide bases induced by metal ions. In: 162nd National Meeting, Amer. Chem. Soc. Abstr. #17, Biol. Chem. Div., Washington, D.C., Sept. 13–17, 1971.

    Google Scholar 

  2. Murray, M. J., and C. P. Flessel, Metal-polynucleotide interactions. A comparison of carcinogenic and non-carcinogenic metals in vitro. Biochim. Biophys. Acta 425: 256–261, 1976.

    PubMed  CAS  Google Scholar 

  3. Shin, Y. A., J. M. Heim, and G. L. Eichorn, Interaction of metal ions with polynucleotides and related compounds. XX. Control of the conformation of polyriboadenylic acid by divalent metal ions. Bioinorg. Chem. 1: 149–163, 1972.

    Article  Google Scholar 

  4. Luke, M. Z., L. Hamilton, and T. C. Hollocher, Beryllium-induced misincorporation of a DNA polymerase. Biochem. Biophys. Res. Commun. 62: 497–501, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. Sirover, M. A., and A. Loeb, On the fidelity of DNA replication. J. Biol. Chem. 252, 3605–3610, 1977.

    PubMed  CAS  Google Scholar 

  6. Hoffman, D. J., and S. K. Niyogi, Metal mutagens and carcinogens affect RNA synthesis rates in a distinct manner. Science 198: 513–514, 1977.

    Article  PubMed  CAS  Google Scholar 

  7. Venitt, S., and L. S. Levy, Mutagenicity of chromates in bacteria and its relevance to chromatic carcinogenesis. Nature 250: 493–495, 1974.

    Article  PubMed  CAS  Google Scholar 

  8. Nishioka, H., Mutagenic activities of metal compounds in bacteria. Mutation Res. 31: 185–189, 1975.

    PubMed  CAS  Google Scholar 

  9. Yagi, T., and H. Nishioka, DNA damage and its degradation by metal compounds. Doshisha Daigaku Rikogaku Kenkyu Hokoku 18: 63–70, 1977.

    CAS  Google Scholar 

  10. Rossman, T. G., M. S. Meyn, and W. Troll, Effects of arsenite on DNA repair in Escherichia coll. Environ. Health Perspect. 19: 229–233, 1977.

    Article  PubMed  CAS  Google Scholar 

  11. Green, M. H. L., W. J. Muriel, and B. A. Bridges, Use of a simplified fluctuation test to detect low levels of mutagens. Mutation Res. 38: 33–42, 1976.

    PubMed  CAS  Google Scholar 

  12. Swierenga, S. H. H., and P. K. Basrur, Effect of nickel on cultured rat embryo muscle cells. Lab. Invest. 19: 663–674, 1968.

    PubMed  CAS  Google Scholar 

  13. Petres, J., and M. Hundeiker, Chromosomal pulverization after arsenic treatment of cell cultures in vitro. Arch. Klin. Exptl Dermatol. 231: 366–370, 1968.

    Article  CAS  Google Scholar 

  14. Petres, J., D. Baron, and M. Hagedorn, Effects of arsenic on cell metabolism and cell proliferation:, cytogenetic and biochemical studies. Environ. Health Perspect. 19: 223–227, 1977.

    Article  PubMed  CAS  Google Scholar 

  15. Nordenson, I., G. Beckman, L. Beckman, and S. Nordstrom, Occupational and environmental risks in and around a smelter in northern Sweden. II. Chromosomal aberrations in workers exposed to arsenic. Hereditas 88: 47–50, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Paton, G. A., and A. C. Allison. Chromosome damage in human cell cultures induced by metal salts. Mutation Res. 16: 332–336, 1972.

    PubMed  CAS  Google Scholar 

  17. Shiraishi, Y., H. Kurahashi, and T. H. Yosida, Chromosomal aberrations in cultured human leukocytes induced by cadmium sulfide. Proc. Japan Acad. 48: 133–137, 1972.

    CAS  Google Scholar 

  18. Rohr, G., and M. Bauchinger, Chromosome analyses in cell cultures of the Chinese hamster after application of cadmium sulfate. Mutation Res. 40: 125–130, 1976.

    Article  PubMed  CAS  Google Scholar 

  19. Felton, T. L., An in vivo study of cadmium-induced chromosomal changes in somatic and germinal tissues of C57B1/6J male mice. Diss. Abstr. Int. B. 38: 4635, 1978.

    Google Scholar 

  20. Tsudo, H., and K. Kato, Potassium dichromate-induced chromosome aberrations and its control with sodium sulfite in hamster embryonic cells in vitro. Gann 67: 469–470, 1976.

    Google Scholar 

  21. Raffetto, G., S. Parodi, C. Parodi, M. de Ferrari, R. Troiano, and G. Brambilla, Direct interaction with celluluar targets as the mechanism for chromium carcinogenesis. Tumori 63: 503–512, 1977.

    PubMed  CAS  Google Scholar 

  22. Costa, M., Alteration in morphology of Chinese hamster ovary cells by Ni3S2 and dibutyryl cAMP. Toxicol. Appl. Pharmacol. 44: 555–566, 1978.

    Article  PubMed  CAS  Google Scholar 

  23. Jung, E. G. And B. Trachsel, Molecular biology of arsenic carcinogenesis. Arch. Klin. Exp. Dermatol. 237: 819–826, 1970.

    Article  PubMed  CAS  Google Scholar 

  24. Jung, E. G., B. Trachsel, and H. Immich, Arsenic as an inhibitor of the enzymes concerned in cellular recovery (dark repair). Germ. Med. Mth. 14: 614–616, 1969.

    CAS  Google Scholar 

  25. Rosen, P., Theoretical significance of arsenic as a carcinogen. J. Theor. Biol. 32: 425–426, 1971.

    Article  PubMed  CAS  Google Scholar 

  26. Levis, A. G., and M. Buttignol, Effects of potassium dichromate on DNA synthesis in hamster fibroblasts. Brit. J. Cancer 35: 496–499, 1977.

    Article  PubMed  CAS  Google Scholar 

  27. Levis, A. G., M. Buttignol, V. Bianchi, and G. Sponza, Effects of potassium dichromate on nucleic acid and protein synthesis and on precursor cells in BHK fibroblasts. Cancer Res. 38: 110–116, 1978.

    PubMed  CAS  Google Scholar 

  28. Fradkin, A., A. Janoff, B. P. Lane, and M. Kuschner, In vitro transformation of BHK21 cells grown in the presence of calcium chromate. Cancer Res. 35: 1058–1063, 1975.

    PubMed  CAS  Google Scholar 

  29. Costa, M., Preliminary report on nickel-induced transformation in tissue culture. In: T. H. Risby (ed.), Ultrace Metals in Biological Systems and the Environment, Advances in Chemistry Series. Vol. 172, pp. 73–90, Washington, D.C., American Chemical Society, 1979.

    Chapter  Google Scholar 

  30. Costa, M., J. Nye, and F. W. Sunderman, Jr., Morphological transformation of Syrian hamster fetal cells induced by nickel compounds. Fed. Proc. 37: 231, 1978.

    Google Scholar 

  31. Costa, M., J. Nye, and F. W. Sunderman, Jr., Morphological transformation of Syrian hamster fetal cells induced by nickel compounds. Ann. Clin. Lab. Sci. 8: 502, 1978.

    Google Scholar 

  32. Costa, M., J. S. Nye, F. W. Sunderman, Jr., P. R. Allpass, and B. Gondos, Induction of sarcomas in nude mice by implantation of Syrian hamster cells exposed in vitro to nickel subsulfide. Cancer Res 39: 3591–3597, 1979.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1980 The Humana Press Inc.

About this protocol

Cite this protocol

Costa, M. (1980). In Vitro and Cell Culture Analysis of Metal Carcinogenesis. In: Metal Carcinogenesis Testing. Biological Methods. Humana Press. https://doi.org/10.1007/978-1-60327-403-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-403-6_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-017-6

  • Online ISBN: 978-1-60327-403-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics