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Rat Genomics pp 389–402Cite as

Genomics Studies of Immune-Mediated Diseases Using the BN–LEW Rat Model

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 597))

Abstract

LEW and BN rats, that behave in opposite ways for their susceptibility to various immune-mediated diseases, provide a powerful model to investigate the molecular and genetic bases of immune system physiology and dysregulation. Using this model, we addressed the question of the genetic control of central nervous system autoimmunity, of xenobiotic-induced allergic diseases, and of T cell subsets that differ by their cytokine profiles. By linkage analysis and genetic dissection, using a panel of congenic rats, we identified a 120 Kb region on chromosome 9 that controls all these phenotypes, indicating that this region contains a gene or set of genes that plays an important role in the immune system homeostasis and susceptibility to immune mediated diseases. In this review, we will describe these rat genomics studies and will discuss the cellular and genetic factors that may be involved in the differences between these rat strains.

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Acknowledgments

The authors thanks the members of Autoimmunity and Immunoregulation team as well as the member of Gilbert Fournié team for their helpful comments and suggestions. We would like also to thank all the dedicated people who participated in this work, in particular, Philippe Druet, Dominique Lagrange, Lucette Pelletier, Magali Mas, Jean-François Subra, Pierre Cavallès, Bastien Cautain, Emmanuel Xystrakis, Céline Colacios, Anne Dejean, Laurence Ordonez, Christine Duthoit, Lucille Lamouroux, Olivier Papapietro, and Audrey Casemayou . We present our apologies to colleagues whose work could not be adequately cited or discussed, due to space limitations. This work was supported by “Institut National de la Santé et de la Recherche Médicale (INSERM),” the Conseil Général de Région Midi-Pyrénées, by grants from “ Agence Nationale de Recherche,” “Association pour la Recherche sur la Sclérose en Plaques,” “Fondation pour la Recherche Médicale,” “Association Française contre les myopathies,” and Arthrithis foundation Courtin.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM) U563, Institut Fédératif de Recherche (IFR) 30, Hôpital Purpan and Université Paul Sabatier, Toulouse, France

    Isabelle Bernard & Abdelhadi Saoudi

  2. INSERM, U563, Toulouse, France

    Gilbert J. Fournié

  3. Université Toulouse III Paul Sabatier, Institut Claude de Préval (IFR30), Toulouse, France

    Gilbert J. Fournié

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  1. Isabelle Bernard
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  2. Gilbert J. Fournié
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  3. Abdelhadi Saoudi
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Correspondence to Abdelhadi Saoudi .

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  1. ITERT-INSERM U643, CHU de Nantes, bd. Jean Monnet 30, Nantes, 44093, France

    Ignacio Anegon

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Bernard, I., Fournié, G.J., Saoudi, A. (2010). Genomics Studies of Immune-Mediated Diseases Using the BN–LEW Rat Model. In: Anegon, I. (eds) Rat Genomics. Methods in Molecular Biology, vol 597. Humana Press. https://doi.org/10.1007/978-1-60327-389-3_26

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  • DOI: https://doi.org/10.1007/978-1-60327-389-3_26

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