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Genetic Polymorphisms and Human Sensitivity to Opioid Analgesics

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Analgesia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 617))

Abstract

Opioid analgesics are commonly used for the treatment of acute as well as chronic, moderate to severe pain. Well-known, however, is the wide interindividual variability in sensitivity to opioids that exists, which has often been a critical problem in pain treatment. To date, only a limited number of studies have addressed the relationship between human genetic variations and sensitivity to opioids, and such studies are still in their early stages. Therefore, revealing the relationship between genetic variations in many candidate genes and individual differences in sensitivity to opioids will provide valuable information for appropriate individualization of opioid doses required for adequate pain control. Although the methodologies for such association studies can be diverse, here we summarize protocols for investigating the association between genetic polymorphisms and sensitivity to opioids in human volunteers and patients undergoing painful surgery.

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Acknowledgments

We acknowledge Mr. Michael Arends for his assistance with editing the manuscript. This work was supported by grants from the Ministry of Health, Labour and Welfare of Japan (H17-Pharmaco-001, H19-Iyaku-023), the Ministry of Education, Culture, Sports, Science and Technology of Japan (20602020, 19659405, 20390162), The Naito Foundation, and The Mitsubishi Foundation.

Author information

Authors and Affiliations

  1. Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan

    Daisuke Nishizawa & Kazutaka Ikeda

  2. Department of Anesthesiology, Saitama Medical University International Medical Center, Hidaka, Japan

    Masakazu Hayashida

  3. Department of Surgery, Toho University Sakura Medical Center, Sakura, Japan

    Makoto Nagashima

  4. Laboratory of Medical Genomics, Department of Human Genome Technology, Kazusa DNA Research Institute, Kisarazu, Japan

    Hisashi Koga

Authors
  1. Daisuke Nishizawa
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  2. Masakazu Hayashida
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  3. Makoto Nagashima
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  4. Hisashi Koga
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  5. Kazutaka Ikeda
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Corresponding author

Correspondence to Kazutaka Ikeda .

Editor information

Editors and Affiliations

  1. Dept. Pathology, Monmouth Medical Center, Second Ave. 300, Long Branch, 07750, USA

    Arpad Szallasi

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Nishizawa, D., Hayashida, M., Nagashima, M., Koga, H., Ikeda, K. (2010). Genetic Polymorphisms and Human Sensitivity to Opioid Analgesics. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_29

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  • DOI: https://doi.org/10.1007/978-1-60327-323-7_29

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-322-0

  • Online ISBN: 978-1-60327-323-7

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