Abstract
The ability to accurately and efficiently manage inventory is critical to ensure cost-effectiveness and guarantee integrity of samples in drug discovery. While many large companies utilise both customised and off-the-shelf automated systems for compound library management, these systems do not come cheaply. Without doubt, for large pharma the return on investment for one of these systems can be justified; however, the upfront cost is typically prohibitive for smaller businesses looking to stretch their limited cash reserves as far as possible. At Exelgen we have shown that for any business with the combination of fit-for-purpose informatics, relatively inexpensive laboratory hardware and well-constructed SOPs (standard operating procedures), it is possible to undertake cost-effective, large-scale compound library management in a small business environment. The informatics and hardware environment deployed at Exelgen are described in detail.
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Exelgen Ltd. (formerly Tripos Discovery Research Ltd.), Bude-Stratton Business Park, Bude, Cornwall, EX23 8LY UK
AstraZeneca UK Ltd., AstraZeneca R&D Alderley Park, Alderley Park, Macclesfield, Cheshire, SK10 4TF UK
IQPC Best Practice for Compound Management & Integrity 2005, May 23rd–25th 2005, The Selfridge Hotel, London
Changing Requirements of Purification as Drug Discovery Programs Evolve from Hit Discovery, John Isbell, J. Comb. Chem., 2008; 10(2), pp. 150–157
MassLynx, Waters Corporation, 34 Maple Street, Milford, MA 01757 USA
Compound Library Management: An Overview of an Automated System Wilma W. Keighley, Terry P. Wood, High Throughput Screening: Methods and Protocols Series: Methods in Molecular Biology, Apr-18-2002; Vol. 190, pp. 129–152
Tripos, 1699 South Hanley Road St. Louis, MO 63144-2319 USA
For example, Symyx Technologies, Inc. 3100 Central Expressway Santa Clara, CA 95051 and ID Business Solutions Ltd., 2 Occam Court, Surrey Research Park, Guildford, Surrey, GU2 7QB UK
Bayer Healthcare, Leverkusen, Germany
Waters Corporation, 34 Maple Street, Milford, MA 01757 USA
Agilent Technologies, Inc., 5301 Stevens Creek Blv, Santa Clara CA 95051 USA
Microsoft Corporation, 1 Microsoft Way, Redmond WA, USA
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© 2009 Humana Press, a part of Springer Science+Business Media, LLC
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Warne, M., Pemberton, L. (2009). Informatics in Compound Library Management. In: Janzen, W., Bernasconi, P. (eds) High Throughput Screening. Methods in Molecular Biology, vol 565. Humana Press. https://doi.org/10.1007/978-1-60327-258-2_3
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DOI: https://doi.org/10.1007/978-1-60327-258-2_3
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Publisher Name: Humana Press
Print ISBN: 978-1-60327-257-5
Online ISBN: 978-1-60327-258-2
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