Skip to main content

Hidden Markov Models in Biology

  • Protocol
  • First Online:
Book cover Data Mining Techniques for the Life Sciences

Part of the book series: Methods in Molecular Biology ((MIMB,volume 609))

Abstract

Markov and Hidden Markov models (HMMs) are introduced using examples from linkage mapping and sequence analysis. In the course, the forward–backward, the Viterbi, the Baum-Welch (EM) algorithm, and a Metropolis sampling scheme are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ewens W (1979) Mathematical Population Genetics. Springer, New York.

    Google Scholar 

  2. Lander E, Green P (1987) Construction of multilocus genetic linkage maps in humans. PNAS 84:2363–2367. Genetics, Linkage map, multipointing.

    Article  CAS  PubMed  Google Scholar 

  3. Lander E, Botstein D (1989) Mapping mendelian factors underlying quantitative traits using rflp linkage maps. Genetics 121:185–199. Genetics, QTL.

    CAS  PubMed  Google Scholar 

  4. Durbin R, Eddy S, Krogh A, Mitchison G (1998) Biological Sequence Analysis. Cambridge University Press, Cambridge.

    Book  Google Scholar 

  5. Haldane J (1919) The combination of linkage values, and the calculation of distances between the loci of linked factors. J Genet 8:299–309.

    Article  Google Scholar 

  6. Baum L (1972) An inequality and associated maximization technique in statistical estimation for probabilistic functions of markov processes. Inequalities 3:1–8.

    Google Scholar 

  7. Gelman A, Carlin J, Stern H, Rubin D (1995) Bayesian Data Analysis. Chapman & Hall, New York.

    Google Scholar 

  8. Liu J (2001) Monte Carlo Strategies in Scientific Computing. Springer, New York.

    Google Scholar 

  9. Kendall W, Liang F, Wang J-S (2005) Markov Chain Monte Carlo: Innovations and Applications. World Scientific, Singapore.

    Book  Google Scholar 

  10. Rabiner L (1989) A tutorial on hidden markov models an selected applications in speech recognition. Proceedings of the IEEE 77: 257–286.

    Article  Google Scholar 

  11. Churchill G (1992) Hidden markov chains and the analysis of genome structure. Comput and Chem 16:107–115.

    Article  CAS  Google Scholar 

  12. Koski T (1992) Hidden Markov Models for Bioinformatics. Kluwer, Dordrecht.

    Google Scholar 

  13. Haussler D, Krogh A, Mian I, Sjolander K (1993) Protein modeling using hidden markov models: analysis of globins. Proc Twenty-Sixth Hawaii Int Conf on Syst Sci 1:792–802.

    Article  Google Scholar 

  14. Burge C, Karlin S (1998) Finding the genes in genomic dna. Curr Opin Struct Biol 8:346–354.

    Article  CAS  PubMed  Google Scholar 

  15. Ball F, Rice J (1992) Stochastic models for ion channels: Introduction and bibliography. Math Biosci 112:189–206.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

CV’s work was funded in part by the FWF (SFB-F28) and AF’s work in part by the WWTF. CV wishes to thank the institute of animal breeding headed by Mathias Müller for support during the writing and especially Christian Schlötterer for encouragement and enthusiasm.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Humana Press, a part of Springer Science+Business Media, LLC

About this protocol

Cite this protocol

Vogl, C., Futschik, A. (2010). Hidden Markov Models in Biology. In: Carugo, O., Eisenhaber, F. (eds) Data Mining Techniques for the Life Sciences. Methods in Molecular Biology, vol 609. Humana Press. https://doi.org/10.1007/978-1-60327-241-4_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-241-4_14

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-240-7

  • Online ISBN: 978-1-60327-241-4

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics