Summary
The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population, and the peptide-binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Nonetheless, the structural basis for HLA supertype-like function is not clearly known. Here, we use structural data to explain the molecular basis for HLA-A2 supertypes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Robinson J., M.J. Waller, P. Parham, N. de Groot, R. Bontrop, L.J. Kennedy, P. Stoehr & S.G.E. Marsh: IMGT/HLA and IMGT/MHC – sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res. 31(1) 311–314 (2003).
Yewdell J.W., E. Reits & J. Neefjes: Making sense of mass destruction – quantitating MHC class I antigen presentation. Nat. Rev. Immunol. 3(12) 952–961 (2003).
Del Guercio M.F., J. Sidney, G. Hermanson, C. Perez, H.M. Grey, R.T. Kubo & A. Sette: Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype. J. Immunol. 154(2) 685–693 (1995).
Sette A. & J. Sidney: Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 50(3–4)201–212 (1999).
Sette A. & J. Sidney: HLA supertypes and supermotifs – a functional perspective on HLA polymorphism. Curr. Opin. Immunol. 10(4) 478–482 (1998).
Sidney J., S. Southwood, V. Pasquetto & A. Sette: Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertype. J. Immunol.171 (11) 5964–5974 (2003).
Chelvanayagam G.: A roadmap for HLA-A, HLA-B, and HLA-C peptide binding specificities. Immunogenetics 45(1) 15–26 (1996).
Zhang C, A. Anderson & C. DeLisi: Structural principles that govern the peptide-binding motifs of class I MHC molecules. J. Mol. Biol. 281(5) 929–947 (1998).
Zhao B., A.E.H. Png, E.C. Ren, P.R. Kolatkar, V.S. Mathura, M.K. Sakharkar & P. Kangueane: Compression of functional space in HLA-A sequence diversity. Hum. Immunol. 64(7) 718–728 (2003).
Doytchinova I.A., P. Guan & D.R. Flower: Identifying human MHC supertypes using bioinformatics methods. J. Immunol. 172(7), 4314–4323 (2004).
Lund O., M. Nielsen, C. Kesmir, A.G. Petersen, C. Lundegaard, P. Worning, C. Sylvester-Hvid, K. Lamberth, G. Roder, S. Justesen, S. Buus & S. Brunak: Definition of supertypes for HLA molecules using clustering of specificity matrices. Immunogenetics 55(12), 797–810 (2004).
Scognamiglio P., D. Accapezzato, M.A. Casciaro, A. Cacciani, M. Artini, G. Bruno, M.L. Chircu, J. Sidney, S. Southwood, S. Abrignani, A. Sette & V. Barnaba: Presence of effector CD8+ T cells in hepatitis C virus-exposed healthy seronegative donors. J. Immunol. 162(11), 6681–6689 (1999).
Kawashima I., S.J. Hudson, V. Tsai, S. Southwood, K. Takesako, E. Appella, A. Sette & E. Celis: The multi-epitope approach for immunotherapy for cancer: identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors. Hum. Immunol. 59(1), 1–14 (1998).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Humana Press Inc.
About this protocol
Cite this protocol
Kangueane, P., Sakharkar, M.K. (2007). Structural Basis for HLA-A2 Supertypes. In: Flower, D.R. (eds) Immunoinformatics. Methods in Molecular Biology™, vol 409. Humana Press. https://doi.org/10.1007/978-1-60327-118-9_10
Download citation
DOI: https://doi.org/10.1007/978-1-60327-118-9_10
Publisher Name: Humana Press
Print ISBN: 978-1-58829-699-3
Online ISBN: 978-1-60327-118-9
eBook Packages: Springer Protocols