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The Human Embryo: Ethical and Legal Aspects

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 550))

Abstract

This paper analyses the status of the embryo in Canadian law. First, a brief overview of some ethical issues raised by research with embryos, focusing on the moral status of the embryo, is presented. A survey of the regulatory framework applicable to embryo research in Canada follows, so as to delineate the legal status of the embryo in Canada and its ethical underpinnings. A summary of applicable regulation in Germany, the United Kingdom, and the United States is also undertaken, illustrating the lack of consensus on this issue in Western countries. Finally, recent developments in stem cell research are considered, focusing on current alternatives to embryo destruction.

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References

  1. Dhonte-Isnard, E. (2004) L’embryon humain in vitro et le droit, Édition L’Harmattan, Paris, France.

    Google Scholar 

  2. Assisted Human Reproduction Act, S.C. 2004, c. 2 (Canada).

    Google Scholar 

  3. Deckers, J. (2007) Why Eberl is wrong. Reflections on the beginning of personhood. Bioethics 21, 270–89.

    Article  PubMed  Google Scholar 

  4. Walin, L. (2007) Ambiguity of the embryo protection in the human rights and biomedicine convention: Experiences from the Nordic countries. Eur. J. Health Law. 14, 131–48.

    Article  PubMed  Google Scholar 

  5. Green, R.M. (2001) The Human Embryo Research Debates: Bioethics in the Vortex of Controversy. Oxford University Press, Oxford, New York.

    Google Scholar 

  6. DeGrazia, D. (2006) Moral status, human identity and early embryos: a Critique of the President’s approach. J. Law Med. Ethics 34, 49–57.

    Article  PubMed  Google Scholar 

  7. Gomez-Lobo, A. (2007) Individuality and human beginnings: A reply to David DeGrazia. J. Law Med. Ethics 35, 457–62.

    Article  PubMed  Google Scholar 

  8. Krones, T., Schlüter, E., Neuwohner, E., El Ansari, S., Wissner, T. and Richter, G. (2006) What is the preimplantation embryo? Soc. Sci. Med. 63, 1–20.

    Article  PubMed  Google Scholar 

  9. Charo, R.A. (2001) Every cell is sacred: Logical consequences of the argument from potential in the age of cloning. In: Lauritzen, P. (ed.), Cloning and the Future of Human Embryo Research. Oxford University Press, Oxford, New York, pp. 82–89.

    Google Scholar 

  10. FitzPatrick, W.J. (2004) Totipotency and the moral status of embryo: new problems for an old argument. J. Soc. Philos. 35, 108–22.

    Article  PubMed  Google Scholar 

  11. Deckers, J. (2007) Why two arguments from probability fail and one argument from Thomson’s analogy of the violinist succeeds in justifying embryo destruction in some situations. J. Med. Ethics 33, 160–64.

    Article  PubMed  CAS  Google Scholar 

  12. Agar, N. (2007) Embryonic potential and stem cells. Bioethics 21, 198–207.

    Article  PubMed  Google Scholar 

  13. Hyun, I. and Jung, K.W. (2006) Human research cloning, embryos, and embryo-like artifacts. Hastings Center Rep. 36, 34.

    Google Scholar 

  14. Singer, P. and Dawson, K. (1988) IVF technology and the argument from potential. Philos. Public Aff. 17, 87.

    PubMed  Google Scholar 

  15. Camporesi, S. (2007) The context of embryonic development and its ethical relevance. Biotechnol. J. 2, 1147–53.

    Article  PubMed  CAS  Google Scholar 

  16. Annas, G. (1996) The politics of human-embryo research: avoiding ethical gridlock. N. Engl. J. Med. 334, 1329–32.

    Article  PubMed  CAS  Google Scholar 

  17. Lizza, J.P. (2007) Potentiality and human embryos. Bioethics 21, 379–85.

    Article  PubMed  Google Scholar 

  18. Tauer, C. (2001) Responsibility and regulation: reproductive technologies, cloning and embryo research. In: Lauritzen, P. (ed.), Cloning and the Future of the Human Embryo. Oxford University Press, Oxford, New York, pp. 145–61.

    Google Scholar 

  19. Elliott, K. (2007) An ironic reductio for a “pro-life” argument: Hurlbut’s proposal for stem cell research. Bioethics 21, 98–110.

    Article  PubMed  Google Scholar 

  20. Steinbock, B. (1992) Life Before Birth – The Moral and Legal Status of Embryos and Fetuses. Oxford University Press, Oxford, New York.

    Google Scholar 

  21. Steinbock, B. (2007) The science, policy and ethics of stem cell research. Reprod. BioMed. Online 14, 130.

    Article  Google Scholar 

  22. Bortolotti, L. and Harris, J. (2005). Stem cell research, personhood and sentience. Reprod. BioMed. Online 10, 68.

    Article  PubMed  Google Scholar 

  23. Royal Commission on New Reproductive Technologies. (1993) Proceed with Care – Final Report of the Royal Commission on New Reproductive Technologies. Minister of Government Services, Ottawa, Canada.

    Google Scholar 

  24. Warnock, M. (1984) Report of the Committee of Inquiry into Human Fertilisation and Embryology. H. M. Stationery Office, London, UK.

    Google Scholar 

  25. National Institutes of Health. (1994) Report of the Human Embryo Research Panel. National Institutes of Health, Bethesda, USA.

    Google Scholar 

  26. Human Fertilisation and Embryology Act 1990, 1990 c. 37 (U.K.), as amended by the Human Fertilisation and Embryology Act 2008, 2008 c. 22 (U.K.) (the “HFE Act”).

    Google Scholar 

  27. Robertson, J.A. (1995) Symbolic issues in embryo research. Hastings Center Rep 25, 37.

    Article  CAS  Google Scholar 

  28. Gibson, S. (2007) Uses of respect and uses of the human embryo. Bioethics 21, 370–78.

    Article  PubMed  Google Scholar 

  29. Beyleveld, D. (2000) Is embryo research and preimplantation diagnosis ethical? Forensic Sci Int. 113, 461–75.

    Article  PubMed  CAS  Google Scholar 

  30. Thévoz, J.-M. (1990) Entre nos mains l’embryon: recherche bioéthique. Labor et Fides, Geneva, Switzerland.

    Google Scholar 

  31. Ryan, M.A. (2001) Creating embryos for research: on weighing symbolic costs. In: Lauritzen, P. (ed.), Cloning and the Future of Embryo Research. Oxford University Press, Oxford, New York, pp. 50–66.

    Google Scholar 

  32. Keenan, J.S.J. (2001) Casuistry, virtue and the slippery slope: major problems with producing human embryonic life for research purposes. In: Lauritzen, P. (ed.), Cloning and the Future of Human Embryo Research. Oxford University Press, Oxford, New York, pp. 67–81.

    Google Scholar 

  33. Steering Committee on Bioethics (CDBI). (2003) The Protection of the Human Embryo In Vitro – Report by the Working Party on the Protection of the Human Embryo and Fetus, Council of Europe, Strasbourg, France.

    Google Scholar 

  34. Deckers, J. (2005) Why current UK legislation on embryo research is immoral. How the argument from lack of qualities and the argument from potentiality have been applied and why they should be rejected. Bioethics 19, 251–71.

    Article  PubMed  Google Scholar 

  35. Callahan, D. (1995) The puzzle of profound respect. Hastings Center Rep. 23, 39.

    Article  Google Scholar 

  36. Campbell, C.S. (2001) Source or resource? Human embryo research as an ethical issue. In: Lauritzen, P. (ed.), Cloning and the Future of Human Embryo Research. Oxford University Press, Oxford, New York, pp. 34–49.

    Google Scholar 

  37. Mykitiuk, R., Nisker, J. and Bluhm, R. (2007) The Canadian assisted human reproduction act: protecting women’s health while potentially allowing human somatic cell nuclear transfer into non-human oocytes. Am. J. Bioeth. 7, 71–73.

    Article  PubMed  Google Scholar 

  38. McLeod, C. and Baylis, F. (2007) Donating fresh versus frozen embryos to stem cell research: in whose interests? Bioethics 21, 465–77.

    Article  PubMed  Google Scholar 

  39. R. v. Morgentaler. (1988) 1 S.C.R. 30.

    Google Scholar 

  40. Tremblay v. Daigle. (1989) 2 S.C.R. 530.

    Google Scholar 

  41. Dobson (Lit. Guardian of) v. Dobson. (1999) 2 S.C.R. 753.

    Google Scholar 

  42. Winnipeg Child and Family Services (NW Area) v. DFG (1997) 3 S.C.R. 925.

    Google Scholar 

  43. R. v. Sullivan. (1991) 1 S.C.R. 489.

    Google Scholar 

  44. NSERC, SSHRC, CIHR. Tri-Council Policy Statement: Conduct of Research Involving Humans, 1998–2005, online: http://www.pre.ethics.gc.ca/english/policystatement/policystatement.cfm, accessed November 14, 2008.

  45. Order in council 1177–2004, December 15, 2004 (G.O.Q. 2005.ii.62), subsequently amended by order in council 73-2006, February 14, 2006 (G.O.Q. 2006.ii.1290).

    Google Scholar 

  46. Renvoi fait par le gouvernement du Québec en vertu de la Loi sur les renvois à la Cour d’appel, L.R.Q. ch. R-23, relativement à la constitutionnalité des articles 8 à 19, 40 à 53, 60, 61 et 68 de la Loi sur la procréation assistée, L.C. 2004, ch. 2 (Dans l’affaire du), 2008 QCCA 1167.

    Google Scholar 

  47. CIHR. (2007) Updated Guidelines for Pluripotent Stem Cell Research, June 29, 2007, online: http://www.cihr-irsc.gc.ca/e/34460.html, accessed November 14, 2008.

  48. ESHRE Task Force on Ethics and Law. (2001) I. The moral status of the pre-implantation embryo. Human Reprod. 16, 1046.

    Article  Google Scholar 

  49. Standing Committee on Health, House of Commons. (2001) Assisted Human Reproduction: Building Families, online: http://cmte.parl.gc.ca/cmte/CommitteePublication.aspx?COM=218&Lang=1&SourceId=213651, accessed November 14, 2008.

  50. Caulfield, T. and Bubela, T. (2007) Why a criminal ban? Analyzing the arguments against somatic cell nuclear transfer in the Canadian parliamentary debate. Am. J. Bioeth. 7, 51–61.

    PubMed  Google Scholar 

  51. Human Fertilisation and Embryology Authority. (2007) HFEA Statement on Donating Eggs for Research, 21 February 2007, online: http://www.hfea.gov.uk/en/1491.html, accessed November 14, 2008.

  52. Act Ensuring the Protection of Embryos in Connection with the Importation and Utilization of Human Embryonic Stem Cells (Stem Cell Act), 28 June 2002, as modified by the Bundestag on April 11, 2008, German Bundestag relaxes Stem Cell Act, online: http://www.bio-pro.de/en/life/magazin/04713/index.html, accessed November 14, 2008.

  53. German National Ethics Council. (2007) Should the Stem Cell Law Be Amended? Opinion, online: http://www.ethikrat.org/_english/publications/Opinion_Should_the_Stem_Cell_Law_be_amended.pdf, accessed November 14, 2008.

  54. Merkel, R. (2007) The legal status of the human embryo. Reprod. BioMed. Online 14, 54.

    Article  Google Scholar 

  55. Public Law 104-99 (The Balanced Budget Downpayment Act, 1), (1996) 104th Congress (U.S.)

    Google Scholar 

  56. Fukuyama, F. and Franco, F. (2008) Beyond bioethics. A Proposal for Modernizing the Regulation of Human Biotechnologies.The Paul H. Nitze School of Advanced International Studies, Washington, DC, available online from: http://www.biotechgov.org/, accessed November 14, 2008.

  57. Stem Cell Research Enhancement Act of 2005 (H.R. 810), (2006) 109th Congress (U.S.)

    Google Scholar 

  58. Stem Cell Research Enhancement Act of 2007 (S. 5), (2007) 110th Congress (U.S.)

    Google Scholar 

  59. Office of the Press Secretary. President Bush Discusses Stem Cell Veto and Executive Order, 2007, online: http://www.whitehouse.gov/news/releases/2007/06/print/20070620-8.html, accessed November 14, 2008.

  60. Executive Order No. 13435, 2007 Federal Register, Vol. 72, No. 120, p. 34589.

    Google Scholar 

  61. Ratajczak, M.Z., Machalinski, B., Wojakowski, W., Ratajczak, J. and Kucia, M. (2007) A hypothesis for an embryonic origin of pluripotent Oct-4(+) stem cells in adult bone marrow and other tissues. Leukemia 21, 860–67.

    PubMed  CAS  Google Scholar 

  62. Zaehres, H. and Scholer, H. (2007) Induction of pluripotency: from mouse to human. Cell 131, 834–35.

    Article  PubMed  CAS  Google Scholar 

  63. Pera, M.F. and Hasegawa, K. (2008) Simpler and safer cell reprogramming. Nat. Biotechnol. 26, 59–60.

    Article  PubMed  CAS  Google Scholar 

  64. European Molecular Biology Organization. (2006) Stem Cell Research – Status Prospects Prerequisites, online: http://www.embo.org/scisoc/EMBO_Stem_Cell_30_nov.pdf, accessed November 14, 2008.

  65. The President’s Council on Bioethics. (2002) Human Cloning and Human Dignity: An Ethical Inquiry, Washington, DC, online: http://bioethics.gov/reports/cloningreport/index.html, accessed November 14, 2008.

  66. Holden, C. (2006) Stem cell research. Korean cloner admits lying about egg donations. Science 310, 1402–03.

    Article  Google Scholar 

  67. Editorial. (2006) Ethics and fraud. Nature 439, 117–18.

    Article  Google Scholar 

  68. Cyranoski, D. (2006) Verdict: Hwang’s human stem cells were all fakes. Nature 439, 122–23.

    Article  PubMed  CAS  Google Scholar 

  69. Park, I.H., Zhao, R., West, J.A., Yabuuchi, A., Huo, H., Ince, T.A., Lerou, P.H., Lensch, M.W. and Daley, G.Q. (2008) Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141–46.

    Article  PubMed  CAS  Google Scholar 

  70. Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., Nie, J., Jonsdottir, G.A., Ruotti, V., Stewart, R., Slukvin, I.I. and Thomson, J.A. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917–20.

    Article  PubMed  CAS  Google Scholar 

  71. Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N. and Yamanaka, S. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26, 101–06.

    Article  PubMed  CAS  Google Scholar 

  72. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861–72.

    Article  PubMed  CAS  Google Scholar 

  73. Chung, Y., Klimanskaya, I., Becker, S., Li, T., Maserati, M., Lu, S.J., Zdravkovic, T., Ilic, D., Genbacev, O., Fisher, S., Krtolica, A. and Lanza, R. (2008) Human embryonic stem cell lines generated without embryo destruction. Cell Stem Cell. 2, 113–17.

    Article  PubMed  CAS  Google Scholar 

  74. Hudson, K. (2006) Embryo biopsy for stem cells: trading old problems for new ones. Hastings Center Rep. 36, 50.

    Article  Google Scholar 

  75. Drukker, M. (2008) Recent advancements towards the derivation of immune-compatible patient-specific human embryonic stem cell lines. Semin. Immunol. 20, 123.

    Article  PubMed  CAS  Google Scholar 

  76. Hurlbut, W.B., George, R.P. and Grompe, M. (2006) Seeking consensus: a clarification and defense of altered nuclear transfer. Hastings Center Rep. 36, 42.

    Article  Google Scholar 

  77. Liao, S.M. (2005) Rescuing human embryonic stem cell research: the blastocyst transfer method. Am. J. Bioeth. 5, 8–16.

    Article  PubMed  Google Scholar 

  78. Philpott, S. (2005) Eggs, lies and compromise. Am. J. Bioeth. 5, 1–3.

    PubMed  Google Scholar 

  79. Assisted Human Reproduction (Section 8 Consent) Regulations (the “Regulations”), SOR/2007-137, P.C. 2007-958, Canada Gazette Part. II, Vol. 14, No. 13, p. 1520.

    Google Scholar 

  80. Human Reproductive Cloning Act 2001, 2001 c. 23 (UK).

    Google Scholar 

  81. HFEA Statement on licensing of applications to carry out research using human-animal cytoplasmic hybrid embryos, online: http://www.hfea.gov.uk/en/1640.html, accessed November 14, 2008.

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Knoppers, B.M., Bordet, S., Isasi, R. (2009). The Human Embryo: Ethical and Legal Aspects. In: Vaillancourt, C., Lafond, J. (eds) Human Embryogenesis. Methods in Molecular Biology, vol 550. Humana Press. https://doi.org/10.1007/978-1-60327-009-0_18

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  • DOI: https://doi.org/10.1007/978-1-60327-009-0_18

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