Abstract
The chromosomes of mammalian genomes exhibit reasonably high levels of similarity that can be used to study small-scale sequence variations. A different approach is to study the evolutionary history of rearrangements in entire genomes based on the analysis of gene or segment orders. We describe three computational tools (GRIMM-Synteny, GRIMM, and MGR) that can be used separately or in succession to contrast different organisms at the genome-level to exploit large-scale rearrangements as a phylogenetic character.
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© 2008 Humana Press Inc., Totowa, NJ
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Tesler, G., Bourque, G. (2008). Computational Tools for the Analysis of Rearrangements in Mammalian Genomes. In: Murphy, W.J. (eds) Phylogenomics. Methods in Molecular Biology™, vol 422. Humana Press. https://doi.org/10.1007/978-1-59745-581-7_10
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DOI: https://doi.org/10.1007/978-1-59745-581-7_10
Publisher Name: Humana Press
Print ISBN: 978-1-58829-764-8
Online ISBN: 978-1-59745-581-7
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