Summary
Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.
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Acknowledgments
l-NNA-induced and DAHP-induced hypertension studies were supported by an American Heart Association Pre-Doctoral Fellowship. DEX-induced hypertension studies were supported by Collaborative Research Center SFB 553, Project A1 from the Deutsche Forschungsgemeinschaft (Bonn).
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Mitchell, B.M., Wallerath, T., Förstermann, U. (2007). Animal Models of Hypertension. In: Sreejayan, N., Ren, J. (eds) Vascular Biology Protocols. Methods in Molecular Medicine™, vol 139. Humana Press. https://doi.org/10.1007/978-1-59745-571-8_6
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DOI: https://doi.org/10.1007/978-1-59745-571-8_6
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Online ISBN: 978-1-59745-571-8
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