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Gene Therapy of Cancer pp 498–513Cite as

Gene Immunotherapy for Non-Small Cell Lung Cancer

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 542))

Summary

Historically, limited results have been observed with immunity in non-small cell lung cancer (NSCLC). In the last 5 years, however, several immune-stimulating products have demonstrated enhancement of tumor antigen recognition through activation of dendritic cell-involved processes. Moreover, clinical benefit has been demonstrated in subsets of patients, justifying ongoing phase III investigation. Results of key gene immunotherapies being tested in NSCLC are reviewed. Preliminary results in advanced NSCLC suggest evidence of well-tolerated immune activation with suggested evidence of clinical benefit with respect to survival and response.

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Authors and Affiliations

  1. Mary Crowley Cancer Research Center, Dallas, TX

    John J. J. Nemunaitis

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  1. John J. J. Nemunaitis
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Correspondence to John J. J. Nemunaitis .

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  1. Molecular Medicine (MDC), Max Delbrück Center for, Robert-Rössle-Str. 10, Berlin, 13125, Germany

    Wolfgang Walther

  2. Molecular Medicine (MDC), Max Delbrück Center for, Robert-Rössle-Str. 10, Berlin, 13125, Germany

    Ulrike S. Stein

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Nemunaitis, J.J. (2009). Gene Immunotherapy for Non-Small Cell Lung Cancer. In: Walther, W., Stein, U. (eds) Gene Therapy of Cancer. Methods in Molecular Biology™, vol 542. Humana Press. https://doi.org/10.1007/978-1-59745-561-9_26

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