Most human platelet alloantigen (HPA) systems comprise biallelic single nucleotide polymorphisms in genes encoding major membrane glycoproteins. Genotyping for these systems is required in the investigation of patients with suspected HPA antibodies and for the provision of compatible blood products from HPA-typed donor panel populations.
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Acknowledgements
The author would like to thank Dr Willem Ouwehand for kind permission to reproduce the cartoon showing graphical representations of platelet glycoproteins in Fig. 4.1.
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McBride, S.E. (2009). Real-Time PCR Assays for High-Throughput Human Platelet Antigen Typing. In: Bugert, P. (eds) DNA and RNA Profiling in Human Blood. METHODS IN MOLECULAR BIOLOGY™, vol 496. Humana Press. https://doi.org/10.1007/978-1-59745-553-4_4
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