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Cancer Gene Profiling in Pancreatic Cancer

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Cancer Gene Profiling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 576))

Summary

High levels of RNases present in the normal pancreas and the abundance of desmoplastic stroma of most pancreatic cancers have traditionally caused difficulty in the extraction of high-quality RNA and gene expression profiling from pancreatic tissues. However, a variety of innovative strategies have made it possible to successfully perform a molecular analysis of pancreatic cancer, and the expression profiles that have been generated have provided tremendous insight into the nature of this aggressive disease. Here, we describe some of these techniques.

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Author information

Authors and Affiliations

  1. Department of Pathology, GI/Liver Division, Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, MD, USA

    Felip Vilardell & Christine A. Iacobuzio-Donahue

Authors
  1. Felip Vilardell
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  2. Christine A. Iacobuzio-Donahue
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Editor information

Editors and Affiliations

  1. Medizinische Fak. Carl Gustav Carus, TU Dresden, Fetscherstr. 74, Dresden, 01307, Germany

    Robert Grützmann

  2. Klinik und Poliklinik für, TU Dresden, Fetscherstraße 74, Dresden, 01307, Germany

    Christian Pilarsky

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Vilardell, F., Iacobuzio-Donahue, C.A. (2009). Cancer Gene Profiling in Pancreatic Cancer. In: Grützmann, R., Pilarsky, C. (eds) Cancer Gene Profiling. Methods in Molecular Biology, vol 576. Humana Press. https://doi.org/10.1007/978-1-59745-545-9_14

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  • DOI: https://doi.org/10.1007/978-1-59745-545-9_14

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-934115-76-3

  • Online ISBN: 978-1-59745-545-9

  • eBook Packages: Springer Protocols

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