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Immune Properties of Mesenchymal Stem Cells

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Book cover Stem Cell Assays

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 407))

Summary

Mesenchymal stem cells (MSCs) are multipotent progenitor cells isolated by various relatively easily accessible tissues, such as bone marrow and cord blood. MSCs gained attention because of their ease for in vitro expansion together with their multilineage potential. More recently, in vitro and in vivo immunosuppressive properties have been ascribed to them, as they are able to modulate the function of all major immune cell populations, thus impeding immune responses. The underlying mechanisms of their differentiation and function are not thoroughly understood, but still they represent important candidates for tissue regeneration and manipulation of the immune response in graft rejection, graft versus host disease, and autoimmune disorders. Characteristics and immunogenic profile of MSCs, their interface with immune system and their potential use as immunosuppressive elements in cellular therapeutic protocols are reviewed in this chapter.

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Authors and Affiliations

  1. Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, Athens, Greece

    Panagiota A. Sotiropoulou & Michael Papamichail

Authors
  1. Panagiota A. Sotiropoulou
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  2. Michael Papamichail
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Editors and Affiliations

  1. Stem Cells, Reprogenetics, West Orange, NJ

    Mohan C. Vemuri

  2. Invitrogen Corporation, Grand Island, NY

    Mohan C. Vemuri

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© 2007 Humana Press

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Sotiropoulou, P.A., Papamichail, M. (2007). Immune Properties of Mesenchymal Stem Cells. In: Vemuri, M.C. (eds) Stem Cell Assays. Methods in Molecular Biology™, vol 407. Humana Press. https://doi.org/10.1007/978-1-59745-536-7_16

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  • DOI: https://doi.org/10.1007/978-1-59745-536-7_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-744-0

  • Online ISBN: 978-1-59745-536-7

  • eBook Packages: Springer Protocols

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