Summary
Receptor distributions in the brain are studied by autoradiographic mapping in brain slices, which is a labor-intensive and expensive procedure. To keep track of the results of such studies, we have designed CoReDat, a multi-user relational database system that is available for download from www.cocomac.org/coredat. Here, we describe the data model and provide an architectural overview of CoReDat for the neuroscientist who wants to use this database, adapt it for related purposes, or build a new one.
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References
Kötter, R. (2001) Neuroscience databases: Tools for exploring brain structure-function relationships. Phil. Trans. R. Soc. Lond. B. 356, 1111–1120.
Dyhrfjeld-Johnsen, J., Maier, J., Schubert, D., Staiger, J. F., Luhmann, H. J., Stephan, K. E., Kötter, R. (2005) CoCoDat: A database system for organizing and selecting quantitative data on single neurons and neuronal microcircuitry. J. Neurosci. Methods 141, 291–308.
Stephan, K. E., Kamper, L., Bozkurt, A., Burns, G. A., Young, M. P., Kötter, R. (2001) Advanced database methodology for the Collation of Connectivity data on the Macaque brain (CoCoMac). Phil. Trans. R. Soc. Lond. B. 356, 1159–1186.
Kötter, R. (2004) Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac database. Neuroinformatics 2, 127–144.
Zilles, K., Schleicher, A., Rath, M., Bauer, A. (1988) Quantitative receptor autoradiography in the human brain. Methodical aspects. Histochemistry 90, 129–137.
Zilles, K., Schleicher, A. (1995) Correlative imaging of transmitter receptor distributions in human cortex, in Autoradiography and Correlative Imaging (Stumpf, W., Solomon, H. eds.). Academic Press, San Diego, CA, pp.277–307.
Kötter, R., Stephan, K. E., Palomero-Gallagher, N., Geyer, S., Schleicher, A., Zilles, K. (2001) Multimodal characterisation of cortical areas by multivariate analyses of receptor binding and connectivity data. Anat. Embryol. 204, 333–350.
Bozkurt, A., Zilles, K., Schleicher, A., Kamper, L., Sanz Arigita, E., Uylings, H., Kötter, R. (2005) Distributions of transmitter receptors in the macaque cingulate cortex. NeuroImage 25, 219–229.
Scheperjans, F., Grefkes, C., Palomero-Gallagher, N., Schleicher, A., Zilles, K. (2005) Subdivisions of human parietal area 5 revealed by quantitative receptor autoradiography: a parietal region between motor, somatosensory, and cingulate cortical areas. NeuroImage 25, 975–992.
Geyer, S., Matelli, M., Luppino, G., Schleicher, A., Jansen, Y, Palomero-Gallagher, N., Zilles, K. (1998) Receptor autoradiographic mapping of the mesial motor and premotor cortex of the macaque monkey. J. Comp. Neurol. 397, 231–250.
Date, C. J. (1990) An Introduction to Database Systems, 5th ed. Addison-Wesley, Reading, MA.
Visel, A., Ahdidan, J., Eichele, G. (2003). A gene expression map of the mouse brain: Genepaint.org– a database of gene expression patterns, in Neuroscience Databases: A Practical Guide (Kötter, R., ed.) Kluwer, Boston, MA, pp.19–36.
Kötter, R., Wanke, E. (2005) Mapping brains without coordinates. Phil. Trans. R. Soc. Lond. B. 360, 751–766.
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Kötter, R., Maier, J., Margas, W., Zilles, K., Schleicher, A., Bozkurt, A. (2007). Databasing Receptor Distributions in the Brain. In: Neuroinformatics. Methods in Molecular Biology™, vol 401. Humana Press. https://doi.org/10.1007/978-1-59745-520-6_15
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DOI: https://doi.org/10.1007/978-1-59745-520-6_15
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