Abstract
Cellular microtubules are rigid in comparison to other cytoskeletal elements (1, 2). To facilitate cytoplasmic remodeling and timely responses to cell signaling events, microtubules depolymerize and repolymerize rapidly at their ends (3). These dynamic properties are critically important for many cellular functions, such as spindle assembly, the capture and segregation of chromosomes during cell division and cell motility. Microtubule dynamics are spatially and temporally controlled in the cell by accessory proteins. Molecular motor proteins of the kinesin superfamily that act to destabilize microtubules play important roles in this regulation (4).
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© 2007 Humana Press Inc., Totowa, NJ
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Stumpff, J. et al. (2007). In Vitro and In Vivo Analysis of Microtubule-Destabilizing Kinesins. In: Sperry, A.O. (eds) Molecular Motors. Methods in Molecular Biology™, vol 392. Humana Press. https://doi.org/10.1007/978-1-59745-490-2_3
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DOI: https://doi.org/10.1007/978-1-59745-490-2_3
Publisher Name: Humana Press
Print ISBN: 978-1-58829-665-8
Online ISBN: 978-1-59745-490-2
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