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Gastric Carcinogenesis and Helicobacter pylori Infection

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Book cover Inflammation and Cancer

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 511))

Summary

Helicobacter pylori is the most frequent cause of infection-induced cancer worldwide. Gastric carcino-genesis is the consequence of the important and life-long inflammation induced by H. pylori in the stomach. Gastric carcinogenesis, can be studied in many ways. In this chapter, we focus on some aspects concerning the bacteria, and others concerning the host. On the bacterial side, the methods exploring the presence of the cag pathogenicity island including cagA and the consequences on epithelial cells are presented. On the host side, tissue microarray, immunohistochemistry and chromogenic in situ hybridization (CISH) are described.

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Author information

Authors and Affiliations

  1. INSERM U853, Université Victor Segalen, Bordeaux, France

    Christine Varon

  2. PU-PH Pathology, INSERM U539, CHU de Nantes, Nantes, France

    Jean-François Mosnier

  3. MCU-PH Bacteriology, INSERM U853, Université Victor Segalen, Bordeaux, France

    Philippe Lehours & Francis Mégraud

  4. MCU-PH, Institut des Maladies de l'Appareil Digestif, Hépato-Gastroentérologie, CHU de Nantes, Nantes, France

    Tamara Matysiak-Budnik

Authors
  1. Christine Varon
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  2. Jean-François Mosnier
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  3. Philippe Lehours
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  4. Tamara Matysiak-Budnik
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  5. Francis Mégraud
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Editor information

Editors and Affiliations

  1. National Cancer Institute at Frederick, SAIC-Frederick, Inc., Frederick, MD, USA

    Serguei V. Kozlov

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© 2009 Springer Science+Business Media, LLC

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Varon, C., Mosnier, JF., Lehours, P., Matysiak-Budnik, T., Mégraud, F. (2009). Gastric Carcinogenesis and Helicobacter pylori Infection. In: Kozlov, S.V. (eds) Inflammation and Cancer. Methods in Molecular Biology™, vol 511. Humana Press. https://doi.org/10.1007/978-1-59745-447-6_10

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  • DOI: https://doi.org/10.1007/978-1-59745-447-6_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-934115-14-5

  • Online ISBN: 978-1-59745-447-6

  • eBook Packages: Springer Protocols

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